The browse option of the database is explained below:
Gene: All the genes present in the database can be browsed. Links to complete information on these genes is also provided. Alternatively there is also a search tab which will aid users in searching for a specific gene. An option to browse by alphabet has also been provided.
SNPs: This option lists all SNPs associated with PCOS, along with links to reference literature and dbSNP database. The search tab provided on this page allows search by gene or SNP ID.
Associated Diseases: The diseases associated with genes present in the database can be viewed using this option. The search tab will aid users in searching for specific diseases.
Pathways: The different metabolic/signalling pathways associated with genes in the database can be browsed. Links to KEGG pathway database is provided here. The search tab allows search of specific pathways.
Ontology terms: The different ontology terms associated with genes in the database can be browsed here. This page displays information on the different ontology terms present in the database, the genes annotated with those ontology terms and the pathways and diseases that the gene is associated with.
The tools section of the database is divided into two sections a) Gene based b) Disease based as described below:
Gene based: The gene based option allows users to analyse the gene-list for common pathways, diseases and ontology terms.
Disease based: This option allows users to retrieve information on genes in the database, their corresponding ontology terms and pathways associated with the user selected disease category. The results of this section displays all diseases grouped under the selected disease category and the genes associated with them.
The analysis section is divided into four sections as described below:
Associated diseases with PCOS: A pie-chart representing the percentage of genes associated with a specific disease category can be visualized here. The genes associated with diseases grouped under the disease category can be accessed by clicking on the respective disease category in the pie-chart.
Pathways: A bar graph of all the pathways that are present in the database is displayed under the pathways section. The number of genes playing a role in each of these pathways is displayed at the top of the bar. The bar representing each pathway is hyperlinked to the KEGG pathway database.
Genes associated with major phenotypes: This section gives the total number of genes associated with PCOS and the most commonly associated phenotypes with PCOS. The genes associated with pathophysiology of these phenotypes can be accessed by clicking on the key provided.
Ontology terms: The ontology terms associated with genes in PCOSKB is represented as a pie-chart. The pie-chart is hyperlinked to the subcategories within each category.