Metabolic process

 

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1 to 1 of 1 Ontology terms
Ontology term Gene (Gene Symbol) Gene Name Pathways Associated Diseases
Positive regulation of transcription from RNA polymerase II promoter
AR Androgen receptor Oocyte meiosis, Pathways in cancer, Prostate cancer Androgen insensitivity syndrome, Virilization, Pseudohermaphroditism, Hypospadias, Azoospermia, Oligozoospermia, Spermatogenesis arrest, Cancer (carcinoma), Infertility, Testicular dysgenesis, Primary amenorrhea, Withdrawal syndrome, Neurodegenerative diseases, Cancer (adenoma), Mental retardation, Obesity, Preeclampsia, Bone loss
ESR1 Estrogen receptor 1 Endocrine and other factor-regulated calcium reabsorption Spontaneous abortion, Infertility, Endometrial hyperplasia, Abnormal follicular development
IGF1 Insulin-like growth factor 1 (somatomedin C) Oocyte meiosis, p53 signaling pathway, mTOR signaling pathway, Focal adhesion, Long-term depression, Progesterone-mediated oocyte maturation, Aldosterone-regulated sodium reabsorption, Pathways in cancer, Glioma, Prostate cancer, Melanoma, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy Acromegaly, Laron syndrome, Short stature, Cancer (adenoma), Pituitary tumors, Pituitary diseases, Osteoporosis, Obesity, Dwarfism, Rabson-mendenhall syndrome, Hyperandrogenism, Hypertrophy, Diabetes mellitus, Polycystic ovaries, Renal failure chronic, Gigantism, Endocrine disorder, Peho syndrome, Retinopathy, Hypothyroidism, Anovulation, Cardiovascular diseases, Noonan syndrome, Acanthosis nigricans, Uremia, Amyotrophic lateral sclerosis, Cancer (prostate carcinoma), Osteoarthritis, Polycystic ovary syndrome (PCOS), Hypopituitarism, Hyperinsulinism
IL6 Interleukin 6 Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Jak-STAT signaling pathway, Hematopoietic cell lineage, Intestinal immune network for IgA production, Prion diseases, Pertussis, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Amoebiasis, Tuberculosis, Measles, Influenza A, Pathways in cancer, Rheumatoid arthritis, Graft-versus-host disease, Hypertrophic cardiomyopathy (HCM) Inflammation, Atherosclerosis, Cardiovascular diseases, Arthritis, Autoimmune diseases, Thrombocytosis, Osteolysis, Acute pancreatitis, Poems syndrome, Lupus erythematosus systemic, Euthyroid sick syndromes, Preterm delivery, Bone loss, Endometriosis, Cancer, Glomerulonephritis mesangial proliferative, Renal disease, Stills disease adult-onset, Anemia, Dyslipidemia, Multiple sclerosis, Niddm, Polycystic ovary syndrome (PCOS), Obesity
INHBA Inhibin, beta A Cytokine-cytokine receptor interaction, TGF-beta signaling pathway Follicle arrest
JUN Jun proto-oncogene MAPK signaling pathway, ErbB signaling pathway, Wnt signaling pathway, Osteoclast differentiation, Focal adhesion, Toll-like receptor signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, Neurotrophin signaling pathway, GnRH signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Pertussis, Leishmaniasis, Chagas disease (American trypanosomiasis), Influenza A, Pathways in cancer, Colorectal cancer, Renal cell carcinoma, Rheumatoid arthritis Cardiac hypertrophy, Vascular diseases, Cancer (carcinoma), Skin tumor, Alzheimers disease, Keloid, Osteoporosis, Multiple sclerosis, Ataxia telangiectasia, Chronic low-grade inflammation
NR5A1 nuclear receptor subfamily 5, group A, member 1 Polycystic ovary syndrome (PCOS), Chronic anovulation, Infertility
POMC Proopiomelanocortin Melanogenesis, Adipocytokine signaling pathway Cushing syndrome, Acth syndrome ectopic, Cancer (adenoma), Obesity, Major depression, Endocrine disorder, Cancer (carcinoma), Hypothyroidism, Alcoholism, Vitiligo, Central diabetes insipidus, Polycystic ovary syndrome (PCOS), Insulin resistance, Adrenal androgen excess
PPARG Peroxisome proliferator-activated receptor gamma PPAR signaling pathway, Osteoclast differentiation, Pathways in cancer, Thyroid cancer Polycystic ovary syndrome (PCOS)
PTH Parathyroid hormone Hypercalcemia, Parathyroid diseases, Osteoporosis, Bone loss, Calcification, Uremia, Cardiovascular diseases, Polycystic ovary syndrome (PCOS)
STAT3 Signal transducer and activator of transcription 3 (acute-phase response factor) Chemokine signaling pathway, Jak-STAT signaling pathway, Adipocytokine signaling pathway, Toxoplasmosis, Hepatitis C, Measles, Pathways in cancer, Pancreatic cancer, Acute myeloid leukemia Inflammation, Polycythemia vera, Obesity, Autoimmune diseases, Primary tumor, Cancer (carcinoma), Autoimmunity, Cardiovascular diseases, Psoriasis
TCF7L2 Transcription factor 7-like 2 (T-cell specific, HMG-box) Diabetes mellitus type 2 , Polycystic ovary syndrome (PCOS), Obesity, Inflammation, Infertility, Hyperandrogenism, Diabetes mellitus, Chronic anovulation, Cardiovascular diseases
TNF Tumor necrosis factor Insulin resistance, Diabetes mellitus type 2 , Obesity, Hypertension, Adipose tissue macrophage (ATM) infiltration, Cardiovascular disease, Low-grade chronic inflammation, Inflammation, Hyperinsulinaemia, Polycystic ovary syndrome (PCOS), Hyperandrogenism
VEGFA Vascular endothelial growth factor A Polycystic ovary syndrome (PCOS), Ovarian hyperstimulation syndrome (OHSS), Cardiovascular diseases
Steroid metabolic process
AKR1C2 Aldo-keto reductase family 1, member C2 Steroid hormone biosynthesis, Metabolism of xenobiotics by cytochrome P450 Cancer
CYP11A1 Cytochrome P450, family 11, subfamily A, polypeptide 1 Steroid hormone biosynthesis, Metabolic pathways Polycystic ovaries, Polyendocrinopathies autoimmune, Virilization, Hyperandrogenism, Endocrine disorder, Aldosteronism primary, Autoimmunity, Cancer (carcinoma), Polycystic ovary syndrome (PCOS)
CYP11B2 Cytochrome P450, family 11, subfamily B, polypeptide 2 Steroid hormone biosynthesis, Metabolic pathways Aldosteronism primary, Essential hypertension, Cancer (adenoma), Liddles syndrome, Hyperkalemia, Cardiovascular diseases, Ventricular hypertrophy, Proteinuria, Atrial fibrillation, Preeclampsia
CYP17A1 Cytochrome P450, family 17, subfamily A, polypeptide 1 Steroid hormone biosynthesis, Metabolic pathways Antley-bixler syndrome, Cancer (adenoma), Primary amenorrhea, Polycystic ovaries, Virilization, Pseudohermaphroditism, Adrenal tumor, Apeced, Aldosteronism primary, Endometriosis, Hypospadias, Rheumatoid arthritis, Cancer (carcinoma), Polycystic ovary syndrome (PCOS), Hyperinsulinism, Hyperandrogenism
CYP19A1 Cytochrome P450, family 19, subfamily A, polypeptide 1 Steroid hormone biosynthesis, Metabolic pathways Polycystic ovary syndrome (PCOS), Endometriosis, Gynecomastia, Virilization, Bone loss, Osteoporosis, Infertility, Antley-bixler syndrome, Polycystic ovaries, Hyperandrogenism, Primary amenorrhea, Short stature, Cancer (carcinoma), Endocrine disorder
CYP21A2 Cytochrome P450, family 21, subfamily A, polypeptide 2 Steroid hormone biosynthesis, Metabolic pathways Virilization, Adrenogenital syndrome, Hyperandrogenism, Pseudohermaphroditism, Antley-bixler syndrome, Apeced, Adrenal tumor, Adrenal disease, Cancer (adenoma), Puberty precocious, Polycystic ovaries, Endocrine disorder, Infertility, Menstrual disorder, Gonadal dysgenesis mixed, Autoimmune diseases, Diabetes mellitus insulin-dependent, Acanthosis nigricans, Obesity, Alopecia androgenetic, Hypospadias, Graves disease, Hypopituitarism, Cardiovascular diseases, Osteoporosis, Congenital hypothyroidism
HSD11B1 Hydroxysteroid (11-beta) dehydrogenase 1 Steroid hormone biosynthesis, Metabolic pathways, Aldosterone-regulated sodium reabsorption Anovulation, Cushing syndrome, Acth deficiency, Dyslipidemia, Cancer (adenoma), Inflammation, Cardiovascular diseases, Osteoporosis, Lipodystrophy, Diabetes mellitus, Obesity, Polycystic ovary syndrome (PCOS)
SRD5A1 Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) Steroid hormone biosynthesis Pseudohermaphroditism, Virilization, Genitalia external ambiguous, Hypospadias, Hyperandrogenism, Polycystic ovaries, Acne vulgaris, Endocrine disorder, Skin diseases, Hyperthyroidism, Cancer (carcinoma), Obesity, Polycystic ovary syndrome (PCOS), Hirsutism
SRD5A2 Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) Steroid hormone biosynthesis, Prostate cancer Virilization, Pseudohermaphroditism, Hypospadias, Gynecomastia, Polycystic ovary syndrome (PCOS)
SULT2A1 Sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 Bile secretion Subfertility, Polycystic ovary syndrome (PCOS), Obesity, Hyperinsulinism, Hyperandrogenism, Hirsutism, Endothelial dysfunction, Dyslipidemia, Cardiovascular diseases, Atherosclerosis, Anovulation, Adrenal androgen excess.
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, Starch and sucrose metabolism, Other types of O-glycan biosynthesis, Retinol metabolism, Porphyrin and chlorophyll metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Metabolic pathways Gilberts syndrome, Crigler-najjar syndrome, Hyperbilirubinemia, Kernicterus, Cholelithiasis, Hemolysis, Cancer, Liver diseases, Solid tumor, Polycystic ovary syndrome (PCOS)
Positive regulation of transcription, DNA-dependent
ACVR1 Activin A receptor, type I Cytokine-cytokine receptor interaction, TGF-beta signaling pathway Fibrodysplasia ossificans progressiva, Ossification heterotopic, Inflammation, Cancer, Polycystic ovary syndrome (PCOS)
AGT Angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Renin-angiotensin system Hypertension arterial, Renal disease, Cardiovascular diseases, Preeclampsia, Glomerulosclerosis, Ventricular hypertrophy, Vesicoureteral reflux, Microalbuminuria, Renovascular, Edema, Diabetes mellitus, Nephrotic syndrome, Retinopathy, Stroke, Diabetes mellitus insulin-dependent, Hypercholesterolemia
AR Androgen receptor Oocyte meiosis, Pathways in cancer, Prostate cancer Androgen insensitivity syndrome, Virilization, Pseudohermaphroditism, Hypospadias, Azoospermia, Oligozoospermia, Spermatogenesis arrest, Cancer (carcinoma), Infertility, Testicular dysgenesis, Primary amenorrhea, Withdrawal syndrome, Neurodegenerative diseases, Cancer (adenoma), Mental retardation, Obesity, Preeclampsia, Bone loss
IGF1 Insulin-like growth factor 1 (somatomedin C) Oocyte meiosis, p53 signaling pathway, mTOR signaling pathway, Focal adhesion, Long-term depression, Progesterone-mediated oocyte maturation, Aldosterone-regulated sodium reabsorption, Pathways in cancer, Glioma, Prostate cancer, Melanoma, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy Acromegaly, Laron syndrome, Short stature, Cancer (adenoma), Pituitary tumors, Pituitary diseases, Osteoporosis, Obesity, Dwarfism, Rabson-mendenhall syndrome, Hyperandrogenism, Hypertrophy, Diabetes mellitus, Polycystic ovaries, Renal failure chronic, Gigantism, Endocrine disorder, Peho syndrome, Retinopathy, Hypothyroidism, Anovulation, Cardiovascular diseases, Noonan syndrome, Acanthosis nigricans, Uremia, Amyotrophic lateral sclerosis, Cancer (prostate carcinoma), Osteoarthritis, Polycystic ovary syndrome (PCOS), Hypopituitarism, Hyperinsulinism
IL1B Interleukin 1, beta Polycystic ovary syndrome (PCOS), Obesity
JUN Jun proto-oncogene MAPK signaling pathway, ErbB signaling pathway, Wnt signaling pathway, Osteoclast differentiation, Focal adhesion, Toll-like receptor signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, Neurotrophin signaling pathway, GnRH signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Pertussis, Leishmaniasis, Chagas disease (American trypanosomiasis), Influenza A, Pathways in cancer, Colorectal cancer, Renal cell carcinoma, Rheumatoid arthritis Cardiac hypertrophy, Vascular diseases, Cancer (carcinoma), Skin tumor, Alzheimers disease, Keloid, Osteoporosis, Multiple sclerosis, Ataxia telangiectasia, Chronic low-grade inflammation
PPARD Peroxisome proliferator-activated receptor delta PPAR signaling pathway, Wnt signaling pathway, Pathways in cancer, Acute myeloid leukemia Polycystic ovary syndrome (PCOS)
PPARGC1A Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha Insulin signaling pathway, Adipocytokine signaling pathway Obesity, Dyslipidemia, Inflammation, Cardiovascular diseases, Diabetes mellitus, Cancer (adenoma), Alzheimers disease, Restenosis, Pulmonary fibrosis, Pituitary tumors, Edema, Bone loss, Renal disease, Multiple sclerosis, Cancer (carcinoma papillary), Chronic obstructive asthma, Liver diseases, Hyperinsulinism, Polycystic ovary syndrome (PCOS)
TNF Tumor necrosis factor Insulin resistance, Diabetes mellitus type 2 , Obesity, Hypertension, Adipose tissue macrophage (ATM) infiltration, Cardiovascular disease, Low-grade chronic inflammation, Inflammation, Hyperinsulinaemia, Polycystic ovary syndrome (PCOS), Hyperandrogenism
WT1 Wilms tumor 1 Denys-drash syndrome, Frasier syndrome, Wagr syndrome, Mesangial sclerosis, diffuse, Nephrotic syndrome, Glomerulosclerosis, Hypospadias, Cryptorchidism, Cancer (adenoma), Cancer (carcinoma), Hypergonadotropic hypogonadism, Renal failure chronic, Hemihypertrophy, Hernia diaphragmatic, Polycystic ovary syndrome (PCOS)
Regulation of transcription, DNA-dependent
CDX2 Caudal type homeobox 2 Cancer (carcinoma), Primary tumor, Polyposis, Inflammation, Ascites, Cysts, Polycystic ovary syndrome (PCOS), Amenorrhea
ESR1 Estrogen receptor 1 Endocrine and other factor-regulated calcium reabsorption Spontaneous abortion, Infertility, Endometrial hyperplasia, Abnormal follicular development
ESR2 Estrogen receptor 2 (ER beta) Polycystic ovary syndrome (PCOS), Infertility, Endometrial hyperplasia
IGF2 Insulin-like growth factor 2 (somatomedin A) Beckwith-wiedemann syndrome, Acromegaly, Hypoglycemic coma, Cancer (carcinoma), Adrenal tumor, Fetal macrosomia, Diabetes mellitus insulin-dependent, Omphalocele, Polycystic ovary syndrome (PCOS), Infertility
INS Insulin Oocyte meiosis, Regulation of autophagy, mTOR signaling pathway, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Type II diabetes mellitus, Type I diabetes mellitus, Maturity onset diabetes of the young, Aldosterone-regulated sodium reabsorption, Prostate cancer Hyperinsulinism, Dyslipidaemia, Insulin secretion, Obesity, Acanthosis nigricans, Androgen Excess, Cardiovascular disease, Polycystic ovary syndrome (PCOS), Hyperandrogenemia , Hyperandrogenism
INSR Insulin receptor Adherens junction, Insulin signaling pathway, Type II diabetes mellitus, Aldosterone-regulated sodium reabsorption Rabson-mendenhall syndrome, Acanthosis nigricans, Obesity, Hyperandrogenism, Diabetes mellitus, Myotonic dystrophy, Dyslipidemia, Fatty liver, Werner syndrome, Skin lesion, Hyperthyroidism, Cancer (adenoma), Cancer (carcinoma), Parkinson disease, Schizophrenia, Retinopathy, Hypertension arterial, Autoimmunity, Polycystic ovary syndrome (PCOS)
NR3C1 Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Neuroactive ligand-receptor interaction Obesity, XY partial gonadal dysgenesis, XX primary ovarian insufficiency, Secondary amenorrhea, Primary Ovarian Insufficiency (POI), Primary amenorrhea, Premature ovarian failure (POF), Infertility, 46 XY disorder of sex development, Polycystic ovary syndrome (PCOS)
PPARD Peroxisome proliferator-activated receptor delta PPAR signaling pathway, Wnt signaling pathway, Pathways in cancer, Acute myeloid leukemia Polycystic ovary syndrome (PCOS)
STAT3 Signal transducer and activator of transcription 3 (acute-phase response factor) Chemokine signaling pathway, Jak-STAT signaling pathway, Adipocytokine signaling pathway, Toxoplasmosis, Hepatitis C, Measles, Pathways in cancer, Pancreatic cancer, Acute myeloid leukemia Inflammation, Polycythemia vera, Obesity, Autoimmune diseases, Primary tumor, Cancer (carcinoma), Autoimmunity, Cardiovascular diseases, Psoriasis
WT1 Wilms tumor 1 Denys-drash syndrome, Frasier syndrome, Wagr syndrome, Mesangial sclerosis, diffuse, Nephrotic syndrome, Glomerulosclerosis, Hypospadias, Cryptorchidism, Cancer (adenoma), Cancer (carcinoma), Hypergonadotropic hypogonadism, Renal failure chronic, Hemihypertrophy, Hernia diaphragmatic, Polycystic ovary syndrome (PCOS)
Positive regulation of sequence-specific DNA binding transcription factor activity
AKT1 V-akt murine thymoma viral oncogene homolog 1 Uterine leiomyomas and endometriosis, Endometrial hyperplasia
ESR1 Estrogen receptor 1 Endocrine and other factor-regulated calcium reabsorption Spontaneous abortion, Infertility, Endometrial hyperplasia, Abnormal follicular development
ESR2 Estrogen receptor 2 (ER beta) Polycystic ovary syndrome (PCOS), Infertility, Endometrial hyperplasia
IL1B Interleukin 1, beta Polycystic ovary syndrome (PCOS), Obesity
IL6 Interleukin 6 Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Jak-STAT signaling pathway, Hematopoietic cell lineage, Intestinal immune network for IgA production, Prion diseases, Pertussis, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Amoebiasis, Tuberculosis, Measles, Influenza A, Pathways in cancer, Rheumatoid arthritis, Graft-versus-host disease, Hypertrophic cardiomyopathy (HCM) Inflammation, Atherosclerosis, Cardiovascular diseases, Arthritis, Autoimmune diseases, Thrombocytosis, Osteolysis, Acute pancreatitis, Poems syndrome, Lupus erythematosus systemic, Euthyroid sick syndromes, Preterm delivery, Bone loss, Endometriosis, Cancer, Glomerulonephritis mesangial proliferative, Renal disease, Stills disease adult-onset, Anemia, Dyslipidemia, Multiple sclerosis, Niddm, Polycystic ovary syndrome (PCOS), Obesity
PPARG Peroxisome proliferator-activated receptor gamma PPAR signaling pathway, Osteoclast differentiation, Pathways in cancer, Thyroid cancer Polycystic ovary syndrome (PCOS)
PPARGC1A Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha Insulin signaling pathway, Adipocytokine signaling pathway Obesity, Dyslipidemia, Inflammation, Cardiovascular diseases, Diabetes mellitus, Cancer (adenoma), Alzheimers disease, Restenosis, Pulmonary fibrosis, Pituitary tumors, Edema, Bone loss, Renal disease, Multiple sclerosis, Cancer (carcinoma papillary), Chronic obstructive asthma, Liver diseases, Hyperinsulinism, Polycystic ovary syndrome (PCOS)
TNF Tumor necrosis factor Insulin resistance, Diabetes mellitus type 2 , Obesity, Hypertension, Adipose tissue macrophage (ATM) infiltration, Cardiovascular disease, Low-grade chronic inflammation, Inflammation, Hyperinsulinaemia, Polycystic ovary syndrome (PCOS), Hyperandrogenism
Positive regulation of protein phosphorylation
ADIPOQ Adiponectin, C1Q and collagen domain containing PPAR signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus Obesity, Cardiovascular diseases, Dyslipidemia, Inflammation, Liver diseases, Diabetes gestational, Diabetes mellitus, Vascular diseases, Anorexia nervosa, Renal disease, Preeclampsia, Apnea sleep, Albuminuria, Hypercholesterolemia, Arteriosclerosis, Proteinuria, Growth hormone deficiency, Ventricular hypertrophy, Cancer (endometrial cancer), Acromegaly, Arthritis, Asthma, Psychotic, Endometriosis, Major depression, Polycystic ovary syndrome (PCOS)
AKT1 V-akt murine thymoma viral oncogene homolog 1 Uterine leiomyomas and endometriosis, Endometrial hyperplasia
IL1B Interleukin 1, beta Polycystic ovary syndrome (PCOS), Obesity
INSR Insulin receptor Adherens junction, Insulin signaling pathway, Type II diabetes mellitus, Aldosterone-regulated sodium reabsorption Rabson-mendenhall syndrome, Acanthosis nigricans, Obesity, Hyperandrogenism, Diabetes mellitus, Myotonic dystrophy, Dyslipidemia, Fatty liver, Werner syndrome, Skin lesion, Hyperthyroidism, Cancer (adenoma), Cancer (carcinoma), Parkinson disease, Schizophrenia, Retinopathy, Hypertension arterial, Autoimmunity, Polycystic ovary syndrome (PCOS)
ITLN1 Intelectin 1 (galactofuranose binding) Cardiovascular diseases, Polycystic ovary syndrome (PCOS)
TGFB1 Transforming growth factor, beta 1 Polycystic ovary syndrome (PCOS)
TNF Tumor necrosis factor Insulin resistance, Diabetes mellitus type 2 , Obesity, Hypertension, Adipose tissue macrophage (ATM) infiltration, Cardiovascular disease, Low-grade chronic inflammation, Inflammation, Hyperinsulinaemia, Polycystic ovary syndrome (PCOS), Hyperandrogenism
VEGFA Vascular endothelial growth factor A Polycystic ovary syndrome (PCOS), Ovarian hyperstimulation syndrome (OHSS), Cardiovascular diseases
Negative regulation of transcription, DNA-dependent
ADIPOQ Adiponectin, C1Q and collagen domain containing PPAR signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus Obesity, Cardiovascular diseases, Dyslipidemia, Inflammation, Liver diseases, Diabetes gestational, Diabetes mellitus, Vascular diseases, Anorexia nervosa, Renal disease, Preeclampsia, Apnea sleep, Albuminuria, Hypercholesterolemia, Arteriosclerosis, Proteinuria, Growth hormone deficiency, Ventricular hypertrophy, Cancer (endometrial cancer), Acromegaly, Arthritis, Asthma, Psychotic, Endometriosis, Major depression, Polycystic ovary syndrome (PCOS)
GATA6 GATA binding protein 6 Adrenal tumor, Cancer (carcinoma)
JUN Jun proto-oncogene MAPK signaling pathway, ErbB signaling pathway, Wnt signaling pathway, Osteoclast differentiation, Focal adhesion, Toll-like receptor signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, Neurotrophin signaling pathway, GnRH signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Pertussis, Leishmaniasis, Chagas disease (American trypanosomiasis), Influenza A, Pathways in cancer, Colorectal cancer, Renal cell carcinoma, Rheumatoid arthritis Cardiac hypertrophy, Vascular diseases, Cancer (carcinoma), Skin tumor, Alzheimers disease, Keloid, Osteoporosis, Multiple sclerosis, Ataxia telangiectasia, Chronic low-grade inflammation
TCF7L2 Transcription factor 7-like 2 (T-cell specific, HMG-box) Diabetes mellitus type 2 , Polycystic ovary syndrome (PCOS), Obesity, Inflammation, Infertility, Hyperandrogenism, Diabetes mellitus, Chronic anovulation, Cardiovascular diseases
TNF Tumor necrosis factor Insulin resistance, Diabetes mellitus type 2 , Obesity, Hypertension, Adipose tissue macrophage (ATM) infiltration, Cardiovascular disease, Low-grade chronic inflammation, Inflammation, Hyperinsulinaemia, Polycystic ovary syndrome (PCOS), Hyperandrogenism
VDR Vitamin D (1,25- dihydroxyvitamin D3) receptor Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Tuberculosis HVDDR, Osteoporosis, Hyperparathyroidism, Bone loss, Psoriasis, Autoimmune diseases, Uremia, Calcification, Multiple sclerosis, Diabetes mellitus insulin-dependent, Cardiovascular diseases, Urolithiasis, Cancer (adenoma), Williams syndrome, Cancer (choriocarcinoma), Graves disease, Arthritis, Primary tumor, Asthma, Inflammation, Polycystic ovary syndrome (PCOS)
WT1 Wilms tumor 1 Denys-drash syndrome, Frasier syndrome, Wagr syndrome, Mesangial sclerosis, diffuse, Nephrotic syndrome, Glomerulosclerosis, Hypospadias, Cryptorchidism, Cancer (adenoma), Cancer (carcinoma), Hypergonadotropic hypogonadism, Renal failure chronic, Hemihypertrophy, Hernia diaphragmatic, Polycystic ovary syndrome (PCOS)
Cholesterol metabolic process
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 ABC transporters, Fat digestion and absorption Alzheimers disease, Amyloid deposition, Cardiovascular diseases, Dyslipidemia, Hypercholesterolemia, Inflammation, Obesity, Polycystic ovary syndrome (PCOS), Renal disease, Stroke, Tangier disease, Xanthomatosis
APOA1 Apolipoprotein A-I PPAR signaling pathway, Fat digestion and absorption, Vitamin digestion and absorption, African trypanosomiasis Obesity, Insulin resistance, Hyperandrogenism, Dyslipidemia, Coronary heart disease
APOB Apolipoprotein B Fat digestion and absorption, Vitamin digestion and absorption Polycystic ovary syndrome (PCOS), Obesity, Metabolic syndrome, Insulin resistance, Hyperprolactinemia, Hyperandrogenism, Dyslipidemia, Cardiovascular diseases, Atherosclerosis
APOE Apolipoprotein E Insulin resistance, Inflammation, Hypertriglyceridaemia, Hyperandrogenism, Atherosclerosis
PPARD Peroxisome proliferator-activated receptor delta PPAR signaling pathway, Wnt signaling pathway, Pathways in cancer, Acute myeloid leukemia Polycystic ovary syndrome (PCOS)
Negative regulation of transcription from RNA polymerase II promoter
EDN1 Endothelin 1 Melanogenesis Polycystic ovary syndrome (PCOS), Insulin resistance, Hyperinsulinism, Hyperandrogenism, Endothelial dysfunction, Dyslipidemia, Cardiovascular diseases
ESR2 Estrogen receptor 2 (ER beta) Polycystic ovary syndrome (PCOS), Infertility, Endometrial hyperplasia
FST Follistatin TGF-beta signaling pathway Polycystic ovaries, Endometriosis, Renal failure chronic, Azoospermia, Inflammation, Liver diseases, Infertility, Atherosclerosis, Miscarriage, Cancer (carcinoma), Polycystic ovary syndrome (PCOS)
GATA6 GATA binding protein 6 Adrenal tumor, Cancer (carcinoma)
STAT3 Signal transducer and activator of transcription 3 (acute-phase response factor) Chemokine signaling pathway, Jak-STAT signaling pathway, Adipocytokine signaling pathway, Toxoplasmosis, Hepatitis C, Measles, Pathways in cancer, Pancreatic cancer, Acute myeloid leukemia Inflammation, Polycythemia vera, Obesity, Autoimmune diseases, Primary tumor, Cancer (carcinoma), Autoimmunity, Cardiovascular diseases, Psoriasis
TCF7L2 Transcription factor 7-like 2 (T-cell specific, HMG-box) Diabetes mellitus type 2 , Polycystic ovary syndrome (PCOS), Obesity, Inflammation, Infertility, Hyperandrogenism, Diabetes mellitus, Chronic anovulation, Cardiovascular diseases
TNF Tumor necrosis factor Insulin resistance, Diabetes mellitus type 2 , Obesity, Hypertension, Adipose tissue macrophage (ATM) infiltration, Cardiovascular disease, Low-grade chronic inflammation, Inflammation, Hyperinsulinaemia, Polycystic ovary syndrome (PCOS), Hyperandrogenism
VDR Vitamin D (1,25- dihydroxyvitamin D3) receptor Endocrine and other factor-regulated calcium reabsorption, Mineral absorption, Tuberculosis HVDDR, Osteoporosis, Hyperparathyroidism, Bone loss, Psoriasis, Autoimmune diseases, Uremia, Calcification, Multiple sclerosis, Diabetes mellitus insulin-dependent, Cardiovascular diseases, Urolithiasis, Cancer (adenoma), Williams syndrome, Cancer (choriocarcinoma), Graves disease, Arthritis, Primary tumor, Asthma, Inflammation, Polycystic ovary syndrome (PCOS)
VEGFA Vascular endothelial growth factor A Polycystic ovary syndrome (PCOS), Ovarian hyperstimulation syndrome (OHSS), Cardiovascular diseases
WT1 Wilms tumor 1 Denys-drash syndrome, Frasier syndrome, Wagr syndrome, Mesangial sclerosis, diffuse, Nephrotic syndrome, Glomerulosclerosis, Hypospadias, Cryptorchidism, Cancer (adenoma), Cancer (carcinoma), Hypergonadotropic hypogonadism, Renal failure chronic, Hemihypertrophy, Hernia diaphragmatic, Polycystic ovary syndrome (PCOS)
Positive regulation of NF-kappaB transcription factor activity
AGER Advanced glycosylation end product-specific receptor Diabetes mellitus, Inflammation, Vascular diseases, Retinopathy, Renal disease, Glomerulosclerosis, Senile plaques, Cardiovascular diseases, Uremia, Amyloidosis, Dementia, Essential hypertension, Restenosis, Preeclampsia, Cancer, Polycystic ovary syndrome (PCOS)
AGT Angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Renin-angiotensin system Hypertension arterial, Renal disease, Cardiovascular diseases, Preeclampsia, Glomerulosclerosis, Ventricular hypertrophy, Vesicoureteral reflux, Microalbuminuria, Renovascular, Edema, Diabetes mellitus, Nephrotic syndrome, Retinopathy, Stroke, Diabetes mellitus insulin-dependent, Hypercholesterolemia
IL1B Interleukin 1, beta Polycystic ovary syndrome (PCOS), Obesity
IL6 Interleukin 6 Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Jak-STAT signaling pathway, Hematopoietic cell lineage, Intestinal immune network for IgA production, Prion diseases, Pertussis, Chagas disease (American trypanosomiasis), African trypanosomiasis, Malaria, Amoebiasis, Tuberculosis, Measles, Influenza A, Pathways in cancer, Rheumatoid arthritis, Graft-versus-host disease, Hypertrophic cardiomyopathy (HCM) Inflammation, Atherosclerosis, Cardiovascular diseases, Arthritis, Autoimmune diseases, Thrombocytosis, Osteolysis, Acute pancreatitis, Poems syndrome, Lupus erythematosus systemic, Euthyroid sick syndromes, Preterm delivery, Bone loss, Endometriosis, Cancer, Glomerulonephritis mesangial proliferative, Renal disease, Stills disease adult-onset, Anemia, Dyslipidemia, Multiple sclerosis, Niddm, Polycystic ovary syndrome (PCOS), Obesity
INS Insulin Oocyte meiosis, Regulation of autophagy, mTOR signaling pathway, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Type II diabetes mellitus, Type I diabetes mellitus, Maturity onset diabetes of the young, Aldosterone-regulated sodium reabsorption, Prostate cancer Hyperinsulinism, Dyslipidaemia, Insulin secretion, Obesity, Acanthosis nigricans, Androgen Excess, Cardiovascular disease, Polycystic ovary syndrome (PCOS), Hyperandrogenemia , Hyperandrogenism
S100A12 Insulin
TNF Tumor necrosis factor Insulin resistance, Diabetes mellitus type 2 , Obesity, Hypertension, Adipose tissue macrophage (ATM) infiltration, Cardiovascular disease, Low-grade chronic inflammation, Inflammation, Hyperinsulinaemia, Polycystic ovary syndrome (PCOS), Hyperandrogenism

 

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