Extracellular region

 

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1 to 1 of 1 Ontology terms
Ontology term Gene (Gene Symbol) Gene Name Pathways Associated Diseases
Extracellular region
AMH Anti-Mullerian hormone Cytokine-cytokine receptor interaction, TGF-beta signaling pathway Pseudohermaphroditism, Cryptorchidism, Azoospermia, Puberty precocious, Cancer (aplasia), Secondary amenorrhea, Polycystic ovary syndrome (PCOS), Obesity, Menstrual irregularities, Insulin resistance, Endometriosis, Infertility, Hyperandrogenism
BGLAP Bone gamma-carboxyglutamate (gla) protein Insulin resistance
CCL2 Chemokine (C-C motif) ligand 2 Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NOD-like receptor signaling pathway, Chagas disease (American trypanosomiasis), Malaria, Influenza A, Rheumatoid arthritis Vascular damage and cardiovascular disease, Polycystic ovary syndrome (PCOS), Obesity, Low-grade chronic inflammation, Hyperinsulinism, Hyperglycemia, Hyperandrogenism, Chronic low-level inflammation, Atherogenesis
CRP C-reactive protein, pentraxin-related Inflammation, Cardiovascular diseases, Atherosclerosis, Obesity, Acute pancreatitis, Arthritis, Dyslipidemia, Lupus erythematosus systemic, Vasculitis, Renal disease, Diabetes mellitus, Microalbuminuria, Stills disease adult-onset, Appendicitis, Stroke, Kawasaki disease, Behcet disease, Restenosis, Arthropathy, Polycystic ovary syndrome (PCOS)
ESR2 Estrogen receptor 2 (ER beta) Polycystic ovary syndrome (PCOS), Infertility, Endometrial hyperplasia
HAMP Hepcidin antimicrobial peptide Insulin resistance
HP Haptoglobin Polycystic ovary syndrome (PCOS), Obesity, Chronic inflammation
IL18 Interleukin 18 Cytokine-cytokine receptor interaction, NOD-like receptor signaling pathway, Cytosolic DNA-sensing pathway, African trypanosomiasis, Malaria, Tuberculosis, Influenza A, Rheumatoid arthritis Diabetes mellitus type 2 , Obesity, Hyperandrogenism, Coronary heart disease, Atherosclerosis
INHA Inhibin, alpha Cancer (adenoma), Hydatidiform mole, Ovarian failure premature, Trophoblastic disease, Cancer (carcinoma), Von hippel-lindau disease, Preeclampsia, Autoimmunity, Polycystic ovary syndrome (PCOS)
INHBB Inhibin, beta B Cytokine-cytokine receptor interaction, TGF-beta signaling pathway Polycystic ovary syndrome (PCOS), Ovarian dysfunction, Insulin resistance, Hypogonadotropic amenorrhea, Hyperandrogenism, Follicle arrest
MIF Macrophage migration inhibitory factor (glycosylation-inhibiting factor) Tyrosine metabolism, Phenylalanine metabolism Inflammation, Arthritis, Autoimmune diseases, Glomerulonephritis, Endometriosis, Aggressiveness, Acute respiratory distress, Atherosclerosis, Allergic reaction, Infertility, Anemia, Acute pancreatitis, Dermatitis atopic, Skin lesion, Cardiovascular diseases, Asthma, Gastrointestinal diseases, Cancer (metaplasia), Autoimmunity, Atopy, Cancer (adenoma), Alzheimers disease, Multiple sclerosis, Polycystic ovary syndrome (PCOS), Obesity, Insulin resistance
NPPB Natriuretic peptide B Cardiac risk
PON1 Paraoxonase 1 Metabolic pathways Atherosclerosis, Cardiovascular diseases, Diabetes mellitus, Hypercholesterolemia, Dyslipidemia, Renal failure chronic, Hyperhomocysteinemia, Antiphospholipid syndrome, Liver damage, Alzheimers disease, Stroke, Lupus erythematosus systemic, Preeclampsia, Obesity, Retinopathy, Uremia, Infertility, Parkinson disease, Ischemia, Asthma, Cancer, Artery stenosis, Nephrotic syndrome, Autistic, Cerebrovascular disease, Behcet disease, Rheumatoid arthritis, Glomerulonephritis, Polycystic ovary syndrome (PCOS)
S100A12 Paraoxonase 1
SERPINF1 Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 Polycystic ovary syndrome (PCOS), Insulin resistance
SHBG Sex hormone-binding globulin Hyperandrogenism, Hypogonadism, Polycystic ovaries, Obesity, Acanthosis nigricans, Cardiovascular diseases, Hyperthyroidism, Hypothyroidism, Virilization, Bone loss, Osteoporosis, Erectile dysfunction, Gynecomastia, Puberty precocious, Anorexia nervosa, Preeclampsia, Diabetes mellitus, Ventricular hypertrophy, Essential hypertension, Atherosclerosis
TGFB2 Transforming growth factor, beta 2 Polycystic ovary syndrome (PCOS)
TNFRSF11B Tumor necrosis factor receptor superfamily, member 11b Cytokine-cytokine receptor interaction, Osteoclast differentiation Proinflammatory state, Insulin resistance, Endothelial dysfunction
Extracellular vesicular exosome
ACE Angiotensin I converting enzyme Renin-angiotensin system, Chagas disease (American trypanosomiasis), Hypertrophic cardiomyopathy (HCM) Albuminuria, Aldosteronism secondary, Atrial fibrillation, Cardiovascular diseases, Cerebrovascular disease, Diabetes mellitus, Dyslipidemia, Erythrocytosis, Essential hypertension, Glomerulosclerosis, Infarct, Nephrotic syndrome, Renal disease, Renovascular, Restenosis, Retinopathy, Sarcoidosis pulmonary, Sclerosis systemic, Stroke, Vascular diseases, Ventricular dilatation, Ventricular dysfunction, Ventricular hypertrophy
APOA1 Apolipoprotein A-I PPAR signaling pathway, Fat digestion and absorption, Vitamin digestion and absorption, African trypanosomiasis Obesity, Insulin resistance, Hyperandrogenism, Dyslipidemia, Coronary heart disease
APOE Apolipoprotein E Insulin resistance, Inflammation, Hypertriglyceridaemia, Hyperandrogenism, Atherosclerosis
C9 complement component 9 Complement and coagulation cascades, Prion diseases, Amoebiasis, Systemic lupus erythematosus Polycystic ovary syndrome (PCOS)
HLA-A Major histocompatibility complex, class I, A Endocytosis, Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, Natural killer cell mediated cytotoxicity, Type I diabetes mellitus, Autoimmune thyroid disease, Allograft rejection, Graft-versus-host disease, Viral myocarditis Diabetes mellitus insulin-dependent, Celiac disease, Psoriasis, Graves disease, Endometriosis, Primary tumor, Autoimmunity, Cancer (carcinoma), Multiple sclerosis
HP Haptoglobin Polycystic ovary syndrome (PCOS), Obesity, Chronic inflammation
IGF2R Insulin-like growth factor 2 receptor Lysosome Polycystic ovary syndrome (PCOS), Inflammation, Diabetes mellitus, Cardiometabolic disease, Abnormal folliculogenesis
KRT18 Keratin 18 Pathogenic Escherichia coli infection Nonalcoholic steatohepatitis
LCN2 Lipocalin 2 Polycystic ovary syndrome (PCOS), Insulin resistance
MEP1A meprin A, alpha (PABA peptide hydrolase) Protein digestion and absorption Polycystic ovary syndrome (PCOS)
MUC1 Mucin 1, cell surface associated Essential hypertension, Cardiovascular diseases, Vitreoretinopathy proliferative, Cancer (adenoma), Preeclampsia, Hypotension, Ischemia, Aldosteronism primary, Inflammation, Adrenal tumor, Arteriosclerosis, Kawasaki disease, Nephrotic syndrome minimal change, Stroke, Lung diseases, Schizophrenia, Cancer (anaplastic astrocytoma), Chronic kidney disease, Arrhythmia, Thrombosis, Asthma, Retinopathy, Ventricular hypertrophy, Cerebrovascular disease, Hyperthyroidism, Endometrial infertility
MUC5AC Mucin 5AC, oligomeric mucus/gel-forming Ocular symptomatology
PRDX2 Peroxiredoxin 2 Visceral adiposity, Diabetes mellitus type 2
RAB5B RAB5B, member RAS oncogene family Ras signaling pathway, Endocytosis, Phagosome, Vasopressin-regulated water reabsorption, Amoebiasis, Tuberculosis Polycystic ovary syndrome (PCOS)
RBP4 Retinol binding protein 4, plasma Vitamin A deficiency, Albuminuria, Renal disease, Liver diseases, Inflammation, Nephrotic syndrome, Hyperostosis diffuse idiopathic skeletal, Dyslipidemia, Zinc deficiency, Diabetes mellitus, Cardiovascular diseases, Hypercholesterolemia, Atherosclerosis, Cancer (carcinoma), Lupus erythematosus systemic, Retinopathy, Alzheimers disease, Cystic fibrosis, Obesity, Polycystic ovary syndrome (PCOS)
SERPINF1 Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 Polycystic ovary syndrome (PCOS), Insulin resistance
SOD1 Superoxide dismutase 1, soluble Peroxisome, Amyotrophic lateral sclerosis (ALS), Prion diseases Endothelial dysfunction, Cardiovascular diseases
STK11 Serine/threonine kinase 11 mTOR signaling pathway, Adipocytokine signaling pathway Ovulatory response
Very-low-density lipoprotein particle
APOA1 Apolipoprotein A-I PPAR signaling pathway, Fat digestion and absorption, Vitamin digestion and absorption, African trypanosomiasis Obesity, Insulin resistance, Hyperandrogenism, Dyslipidemia, Coronary heart disease
APOB Apolipoprotein B Fat digestion and absorption, Vitamin digestion and absorption Polycystic ovary syndrome (PCOS), Obesity, Metabolic syndrome, Insulin resistance, Hyperprolactinemia, Hyperandrogenism, Dyslipidemia, Cardiovascular diseases, Atherosclerosis
APOC1 Apolipoprotein C-I Cardiovascular risk
APOE Apolipoprotein E Insulin resistance, Inflammation, Hypertriglyceridaemia, Hyperandrogenism, Atherosclerosis
High-density lipoprotein particle
APOA1 Apolipoprotein A-I PPAR signaling pathway, Fat digestion and absorption, Vitamin digestion and absorption, African trypanosomiasis Obesity, Insulin resistance, Hyperandrogenism, Dyslipidemia, Coronary heart disease
APOC1 Apolipoprotein C-I Cardiovascular risk
APOE Apolipoprotein E Insulin resistance, Inflammation, Hypertriglyceridaemia, Hyperandrogenism, Atherosclerosis
PON1 Paraoxonase 1 Metabolic pathways Atherosclerosis, Cardiovascular diseases, Diabetes mellitus, Hypercholesterolemia, Dyslipidemia, Renal failure chronic, Hyperhomocysteinemia, Antiphospholipid syndrome, Liver damage, Alzheimers disease, Stroke, Lupus erythematosus systemic, Preeclampsia, Obesity, Retinopathy, Uremia, Infertility, Parkinson disease, Ischemia, Asthma, Cancer, Artery stenosis, Nephrotic syndrome, Autistic, Cerebrovascular disease, Behcet disease, Rheumatoid arthritis, Glomerulonephritis, Polycystic ovary syndrome (PCOS)
Chylomicron
APOB Apolipoprotein B Fat digestion and absorption, Vitamin digestion and absorption Polycystic ovary syndrome (PCOS), Obesity, Metabolic syndrome, Insulin resistance, Hyperprolactinemia, Hyperandrogenism, Dyslipidemia, Cardiovascular diseases, Atherosclerosis
APOC1 Apolipoprotein C-I Cardiovascular risk
APOE Apolipoprotein E Insulin resistance, Inflammation, Hypertriglyceridaemia, Hyperandrogenism, Atherosclerosis
Low-density lipoprotein particle
APOB Apolipoprotein B Fat digestion and absorption, Vitamin digestion and absorption Polycystic ovary syndrome (PCOS), Obesity, Metabolic syndrome, Insulin resistance, Hyperprolactinemia, Hyperandrogenism, Dyslipidemia, Cardiovascular diseases, Atherosclerosis
APOE Apolipoprotein E Insulin resistance, Inflammation, Hypertriglyceridaemia, Hyperandrogenism, Atherosclerosis
PLA2G7 Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) Ether lipid metabolism, Metabolic pathways Atherosclerosis, Inflammation, Acute respiratory distress, Hypercholesterolemia, Dyslipidemia, Anaphylaxis, Asthma, Uremic syndrome, Renal disease, Arthritis juvenile rheumatoid, Stroke, Lupus erythematosus systemic, Nephrotic syndrome, Diabetes mellitus insulin-dependent, Lung diseases, Subarachnoid hemorrhage, Allergic reaction, Cancer (colorectal cancer), Diabetes mellitus, Polycystic ovary syndrome (PCOS)
Intermediate-density lipoprotein particle
APOB Apolipoprotein B Fat digestion and absorption, Vitamin digestion and absorption Polycystic ovary syndrome (PCOS), Obesity, Metabolic syndrome, Insulin resistance, Hyperprolactinemia, Hyperandrogenism, Dyslipidemia, Cardiovascular diseases, Atherosclerosis
APOE Apolipoprotein E Insulin resistance, Inflammation, Hypertriglyceridaemia, Hyperandrogenism, Atherosclerosis
Spherical high-density lipoprotein particle
APOA1 Apolipoprotein A-I PPAR signaling pathway, Fat digestion and absorption, Vitamin digestion and absorption, African trypanosomiasis Obesity, Insulin resistance, Hyperandrogenism, Dyslipidemia, Coronary heart disease
PON1 Paraoxonase 1 Metabolic pathways Atherosclerosis, Cardiovascular diseases, Diabetes mellitus, Hypercholesterolemia, Dyslipidemia, Renal failure chronic, Hyperhomocysteinemia, Antiphospholipid syndrome, Liver damage, Alzheimers disease, Stroke, Lupus erythematosus systemic, Preeclampsia, Obesity, Retinopathy, Uremia, Infertility, Parkinson disease, Ischemia, Asthma, Cancer, Artery stenosis, Nephrotic syndrome, Autistic, Cerebrovascular disease, Behcet disease, Rheumatoid arthritis, Glomerulonephritis, Polycystic ovary syndrome (PCOS)
Mature chylomicron
APOB Apolipoprotein B Fat digestion and absorption, Vitamin digestion and absorption Polycystic ovary syndrome (PCOS), Obesity, Metabolic syndrome, Insulin resistance, Hyperprolactinemia, Hyperandrogenism, Dyslipidemia, Cardiovascular diseases, Atherosclerosis
Chylomicron remnant
APOB Apolipoprotein B Fat digestion and absorption, Vitamin digestion and absorption Polycystic ovary syndrome (PCOS), Obesity, Metabolic syndrome, Insulin resistance, Hyperprolactinemia, Hyperandrogenism, Dyslipidemia, Cardiovascular diseases, Atherosclerosis

 

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