UCP2

Gene Information
 
Gene Symbol
UCP2
 
Aliases
BMIQ4, SLC25A8, UCPH
 
Entrez Gene ID
 
Gene Name
Uncoupling protein 2 (mitochondrial, proton carrier)
 
Chromosomal Location
11q13
 
HGNC ID
 
Summary
 
GeneCards ID
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006810 Biological process Transport NAS 9196039
Protein Information
 
Protein Name
Mitochondrial uncoupling protein 2
 
Function
SwissProt: P55851 # UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00153 Mito_carr Mitochondrial carrier protein
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Hyperandrogenism 21557918
   
References
 
Primary:

Abnormal expression of uncoupling protein-2 correlates with CYP11A1 expression in polycystic ovary syndrome.

Liu Yun, Jiang Hong, He Ling-Yun, Huang Wu-Jian, He Xiao-Yu, Xing Fu-Qi
Center for Reproductive Medicine, Fuzhou General Hospital, Fuzhou, Fujian Province, China. liuyun95@yahoo.com.cn
Reprod Fertil Dev. 2011;23(4):520-6. doi: 10.1071/RD10266.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
CYP11A1 
Hyperandrogenaemia 
 
 
Related 
 
 In conclusion, in PCOS patients, there was a correlation between UCP-2 and CYP11A1 expression, which was significantly higher than in the control group. These changes in UCP-2 and CYP11A1 expression may mediate follicle development in PCOS. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25566617
[Effect of modified cangfu daotan decoction in improving endometrial receptivity in infertility patients with polycystic ovarian syndrome]. 
Clinical study 
23008094
Uncoupling protein 2 expression affects androgen synthesis in polycystic ovary syndrome. 
Clinical study 
21584501
Association study between the -866G/A polymorphism in the promoter of uncoupling protein-2 gene and polycystic ovary syndrome. 
Clinical study 

 

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