TPO

Gene Information
 
Gene Symbol
TPO
 
Aliases
MSA, TDH2A, TPX
 
Entrez Gene ID
 
Gene Name
Thyroid peroxidase
 
Chromosomal Location
2p25
 
HGNC ID
 
Summary
This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. (provided by RefSeq, May 2011)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0005887 Cellular component Integral component of plasma membrane TAS 2548579
GO:0004601 Molecular function Peroxidase activity TAS 3475693
Protein Information
 
Protein Name
Thyroperoxidase , TPX , thyroid microsomal antigen , MSA , thyroid peroxidase, TDH2A , EC 1.11.1.8
 
Function
Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4)
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF03098 An_peroxidase Animal haem peroxidase
PF07645 EGF_CA Calcium-binding EGF domain
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Autoimmune thyroiditis 15012623
   
References
 
Primary:

High prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome.

Janssen Onno E, Mehlmauer Nadine, Hahn Susanne, Offner Alexandra H, Gartner Roland
Division of Endocrinology, Department of Medicine, University of Essen, Essen, Germany.
Eur J Endocrinol. 2004 Mar;150(3):363-9.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
Autoimmune thyroiditis,Increased estrogen-to-progesterone ratio 
 
NIH 
Related 
 
Elevated thyroperoxidase (TPO) was observed in 26.9% of PCOS patients 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25822940
High prevalence of Hashimoto's thyroiditis in patients with polycystic ovary syndrome: does the imbalance between estradiol and progesterone play a role? 
Clinical study 
25522724
Frequency of nodular goiter and autoimmune thyroid disease in patients with polycystic ovary syndrome. 
Clinical study 
25485530
The prevalence of non organ specific and thyroid autoimmunity in patients with polycystic ovary syndrome. 
Clinical study 
25237328, PMC4166006
Detection of thyroid autoimmunity markers in euthyroid women with polycystic ovary syndrome: a case-control study from syria. 
Clinical study 
25211537
Polycystic ovary syndrome and chronic autoimmune thyroiditis. 
Clinical study 

 

| © 2015, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412