TNFRSF1B

Gene Information
 
Gene Symbol
TNFRSF1B
 
Aliases
CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR
 
Entrez Gene ID
 
Gene Name
Tumor necrosis factor receptor superfamily, member 1B
 
Chromosomal Location
1p36.22
 
HGNC ID
 
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0033209 Biological process Tumor necrosis factor-mediated signaling pathway TAS 8702885
GO:0045121 Cellular component Membrane raft IDA 17010968
GO:0005515 Molecular function Protein binding IPI 8069916
Protein Information
 
Protein Name
Tumor necrosis factor-binding protein 2
 
Function
Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
Accessions
IPR001368, IPR020411
 
Pfam
Pfam Accession Pfam ID
PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
 
KEGG
 
OMIM
 
Interactions

Associated Diseases

Diseases References
Arthritis 11358427, 16947419, 12858186, 10023437, 16689106, 17728335, 19210888, 20346252, 1416553, 16277691, 16385499, 10765919, 18240242, 8436419, 14582328, 15120191, 17728335, 9290265, 10765919, 15022314, 15603867, 17502870, 19222252, 17394851, 12011375, 8733441, 17502870, 10717011, 17394851, 9290265, 17223661, 10806045, 18484150
Cancer (carcinoma) 18764880, 18206417, 8119765, 12701963
Cardiovascular diseases 17172268
Endometriosis 20172870, 14506926, 18510047, 15212671
Essential hypertension 11315843, 19557004
   
References
 
Primary:

Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism.

Peral Belen, San Millan Jose L, Castello Roberto, Moghetti Paolo, Escobar-Morreale Hector F
Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, 28029 Madrid, Spain.
J Clin Endocrinol Metab. 2002 Aug;87(8):3977-83.

 

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