TNFRSF11B

Gene Information
 
Gene Symbol
TNFRSF11B
 
Aliases
OCIF, OPG, PDB5, TR1
 
Entrez Gene ID
 
Gene Name
Tumor necrosis factor receptor superfamily, member 11b
 
Chromosomal Location
8q24
 
HGNC ID
 
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. (provided by RefSeq, Jul 2008)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0001501 Biological process Skeletal system development TAS 9108485
GO:0005576 Cellular component Extracellular region TAS 9108485
GO:0005615 Cellular component Extracellular space IDA 15516325
GO:0004872 Molecular function Receptor activity TAS 9108485
GO:0005125 Molecular function Cytokine activity TAS 9168977
Protein Information
 
Protein Name
Tumor necrosis factor receptor superfamily member 11B
 
Function
Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00020 TNFR_c6 TNFR/NGFR cysteine-rich region
PF00531 Death Death domain
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Endothelial dysfunction 20974706
Insulin resistance 20974706
Proinflammatory state 18579554
   
References
 
Primary:

Circulating osteoprotegerin and soluble receptor activator of nuclear factor kappaB ligand in polycystic ovary syndrome: relationships to insulin resistance and endothelial dysfunction.

Pepene Carmen Emanuela, Ilie Ioana Rada, Marian Ioan, Duncea Ileana
Departments of Endocrinology Internal Medicine-Cardiology, University of Medicine and Pharmacy Cluj-Napoca, 3-5 Louis Pasteur, 400349 Cluj-Napoca, Romania. c_e_georgescu@yahoo.com
Eur J Endocrinol. 2011 Jan;164(1):61-8. doi: 10.1530/EJE-10-0720. Epub 2010 Oct
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
Endothelial dysfunction,insulin resistance 
 
 
Related 
 
In PCOS, circulating OPG is related to both endothelial dysfunction and insulin resistance, independent of obesity and androgen excess, suggesting OPG as a useful biomarker of these effects. 
 
Proinflammatory state,cardiovascular risk 
 
 
Related 
 
Serum OPG concentrations are reduced in PCOS patients independently of obesity. 

 

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