TM4SF4

Gene Information
 
Gene Symbol
TM4SF4
 
Aliases
ILTMP, il-TMP
 
Entrez Gene ID
 
Gene Name
Transmembrane 4 L six family member 4
 
Chromosomal Location
3q25
 
HGNC ID
 
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.(provided by RefSeq, Mar 2011)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein
Protein Information
 
Protein Name
Transmembrane 4 L6 family member 4
 
Function
Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation
 
Refseq Proteins
 
UniProt
 
InterPro
Accessions
IPR008661
 
Pfam
Pfam Accession Pfam ID
PF05805 L6_membrane L6 membrane protein
 
OMIM

Associated Diseases

Diseases References
Miscarriage 18765015
   
References
 
Primary:

Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome.

Qiao Jie, Wang Lina, Li Rong, Zhang Xiaowei
Reproductive Medicine Centre, Peking University Third Hospital, Beijing 100083, China.
Reprod Biomed Online. 2008 Sep;17(3):425-35.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
MMP26 
Lower pregnancy and higher miscarriage rates,endometrial receptivity 
 
 
Related 
 
 It is suggested the down-regulated gene expression during the implantation window in patients with PCOS indicates differential gene expression in the endometrium between PCOS and normal women during the implantation window. This might affect endometrial receptivity. 

 

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