STS

Gene Information
 
Gene Symbol
STS
 
Aliases
ARSC, ARSC1, ASC, ES, SSDD, XLI
 
Entrez Gene ID
412
 
Gene Name
Steroid sulfatase (microsomal), isozyme S
 
Chromosomal Location
Xp22.32
 
HGNC ID
 
Summary
The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to estrogens during pregnancy. The encoded protein is found in the endoplasmic reticulum, where it acts as a homodimer. Mutations in this gene are known to cause X-linked ichthyosis (XLI). (provided by RefSeq, Jul 2008)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006706 Biological process Steroid catabolic process TAS 6957717
GO:0008544 Biological process Epidermis development TAS 9252398
GO:0005764 Cellular component Lysosome TAS 2668275
GO:0005768 Cellular component Endosome TAS 2668275
GO:0005783 Cellular component Endoplasmic reticulum TAS 2668275
Protein Information
 
Protein Name
Steryl-sulfatase
 
Function
Conversion of sulfated steroid precursors to estrogens during pregnancy
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00884 Sulfatase Sulfatase
PF14707 Sulfatase_C C-terminal region of aryl-sulfatase
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Steroid metabolism 18467089
   
References
 
Primary:

In situ estrogen metabolism in proliferative endometria from untreated women with polycystic ovarian syndrome with and without endometrial hyperplasia.

Bacallao K, Leon L, Gabler F, Soto E, Romero C, Valladares L, Vega M
Institute of Maternal and Child Research, School of Medicine, University of Chile, Chile; Department of Obstetrics and Gynecology, School of Medicine, University of Chile, Clinical Hospital, Santos Dumont # 999, Santiago, Chile.
J Steroid Biochem Mol Biol. 2008 May;110(1-2):163-9. doi:
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
P450 aromatase, estrogen sulfotransferase (EST) and 17beta-hydroxysteroid dehydrogenase (17beta-HSD) 
Steroid metabolism 
 
 
Related 
 
The relationship between the activities of STS and EST was lower in PCOSE and HPCOSE (p<0.05) versus CE. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
23122578
Placental steroidogenesis in pregnant women with polycystic ovary syndrome. 
Clinical study 

 

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