STAT3

Gene Information
 
Gene Symbol
STAT3
 
Aliases
ADMIO, APRF, HIES
 
Entrez Gene ID
 
Gene Name
Signal transducer and activator of transcription 3 (acute-phase response factor)
 
Chromosomal Location
17q21
 
HGNC ID
 
Summary
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0000122 Biological process Negative regulation of transcription from RNA polymerase II promoter TAS 8675499
GO:0006355 Biological process Regulation of transcription, DNA-templated IDA 15664994
GO:0006606 Biological process Protein import into nucleus IDA 18234692
GO:0006928 Biological process Cellular component movement TAS 9670957
GO:0007165 Biological process Signal transduction TAS 10205054
Protein Information
 
Protein Name
Signal transducer and activator of transcription 3
 
Function
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00017 SH2 SH2 domain
PF01017 STAT_alpha STAT protein, all-alpha domain
PF02864 STAT_bind STAT protein, DNA binding domain
PF02865 STAT_int STAT protein, protein interaction domain
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Autoimmune diseases 17878325, 18777586, 20159113
Autoimmunity 17878325, 14499117, 20493732, 19648026
Cancer (carcinoma) 19173990, 16407846, 15590419, 19956438, 10925276, 17441424, 11934261, 18758380, 11278729, 16648865, 17549669, 15688010, 15485908, 19424608, 17557905, 16737614, 17545518, 11104703, 12833138, 17264243, 9843726
Cardiovascular diseases 18786563, 16807407
Inflammation 20196117, 19851315, 15677901, 20493732, 17030178, 16539688, 17543278, 20040863, 15561981, 19616846, 11181699, 16682432, 17532542, 18620071, 15905571, 16857804, 19665497, 17028263, 16835372, 16199153, 7519723, 19452285, 19778555, 18556750, 18069684, 18560602, 17574099, 19088040, 18395093, 16920482, 17530315, 17438334, 16951338, 19665429, 18055558, 17302908, 15963355, 19737863, 19185839, 17198696, 17187052, 17122147, 9266835, 17918316, 20354188, 15947106, 19282476, 19440292, 19723038
   
References
 
Primary:

Association of serum and follicular fluid leptin concentrations with granulosa cell phosphorylated signal transducer and activator of transcription 3 expression in fertile patients with polycystic ovarian syndrome.

Li Mei-Gen, Ding Guo-Lian, Chen Xi-Jing, Lu Xi-Ping, Dong Li-Jun, Dong Min-Yue, Yang Xiao-Fu, Lu Xiu-E, Huang He-Feng
Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, 2 Xue Shi Road, Hangzhou, Zhejiang, 31006, China.
J Clin Endocrinol Metab. 2007 Dec;92(12):4771-6. Epub 2007 Sep 25.

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25609240
Placental STAT3 signaling is activated in women with polycystic ovary syndrome. 
Clinical study 
25450293
Leptin down-regulates ??-ENaC expression: a novel mechanism involved in low endometrial receptivity. 
In vitro 
24719790, PMC3979881
Developmental androgenization programs metabolic dysfunction in adult mice: Clinical implications. 
Animal study 
21819988
Effects of androgen and leptin on behavioral and cellular responses in female rats. 
Animal study 

 

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