STAR

Gene Information
 
Gene Symbol
STAR
 
Aliases
STARD1
 
Entrez Gene ID
 
Gene Name
Steroidogenic acute regulatory protein
 
Chromosomal Location
8p11.2
 
HGNC ID
 
Summary
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006694 Biological process Steroid biosynthetic process TAS 7761400
Protein Information
 
Protein Name
Steroidogenic acute regulatory protein, mitochondrial
 
Function
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF01852 START START domain
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Alzheimers disease 17018137
Cancer (adenoma) 9398748, 8708561
Endometriosis 19930843, 11739437, 18583320, 12933667, 19001523, 18165439
Hyperlipidemia 15863358
Ovarian failure premature 15059956
   
References
 
Primary:

Steroidogenic acute regulatory protein (StAR) in the ovaries of healthy women and those with polycystic ovary syndrome.

Kahsar-Miller M D, Conway-Myers B A, Boots L R, Azziz R
Laboratory of Medical Genetics, The University of Alabama at Birmingham, USA.
Am J Obstet Gynecol. 2001 Dec;185(6):1381-7.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
LH, 20-HSD, P450arom 
 
 
 
Related 
 
The mRNA expression corresponding to steroidogenic acute regulatory protein (StAR), and 20alpha-hydroxysteroid dehydrogenase (20-HSD) was increased, while that corresponding to cytochrome P450 aromatase (P450arom) was decreased in PCOS follicles as compared to controls. 
CYP11A, LHR, CYP17 
 
 
Women with PCOS were identified based on a history of oligo/amenorrhea, hirsutism, and typical morphological appearance of polycystic ovaries (normal or enlarged ovarian volume with multiple subcapsular cysts <8 mm in diameter) at laparotomy or laparoscop 
Related 
 
The mean levels of LH receptor, StAR, CYP11A, and CYP17 mRNA expression were higher in thecal cells fromPCOS follicles than in size-matched control follicles. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26357661, PMC4556819
Paracrine Regulation of Steroidogenesis in Theca Cells by Granulosa Cells Derived from Mouse Preantral Follicles. 
Animal study 
25061847, PMC4138569
Developmental programming: prenatal steroid excess disrupts key members of intraovarian steroidogenic pathway in sheep. 
Animal study 
24943040
Expression and regulation of INTELECTIN1 in human granulosa-lutein cells: role in IGF-1-induced steroidogenesis through NAMPT. 
In vitro 
23546603
Excess androgens in utero alters fetal testis development. 
Clinical study 
23152920, PMC3495868
The anti-epileptic drug valproic acid (VPA) inhibits steroidogenesis in bovine theca and granulosa cells in vitro. 
Effect of treatment 

 

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