SOCS3

Gene Information
 
Gene Symbol
SOCS3
 
Aliases
ATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3
 
Entrez Gene ID
 
Gene Name
Suppressor of cytokine signaling 3
 
Chromosomal Location
17q25.3
 
HGNC ID
 
Summary
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006469 Biological process Negative regulation of protein kinase activity TAS 9266833
GO:0007259 Biological process JAK-STAT cascade TAS 9266833
GO:0004860 Molecular function Protein kinase inhibitor activity TAS 9266833
GO:0005515 Molecular function Protein binding IPI 19027008
Protein Information
 
Protein Name
Suppressor of cytokine signaling 3
 
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity)
 
Refseq Proteins
 
UniProt
 
InterPro
Accessions
IPR001496, IPR000980
 
Pfam
Pfam Accession Pfam ID
PF00017 SH2 SH2 domain
PF07525 SOCS_box SOCS box
 
KEGG
 
OMIM

Associated Diseases

Diseases References
Allergic reaction 16476192
Arthritis 11748261, 17966396, 18820827
Asthma 12847520
Atherosclerosis 19737863, 19083014
Autoimmunity 19643666
   
References
 
Primary:

Association of serum and follicular fluid leptin concentrations with granulosa cell phosphorylated signal transducer and activator of transcription 3 expression in fertile patients with polycystic ovarian syndrome.

Li Mei-Gen, Ding Guo-Lian, Chen Xi-Jing, Lu Xi-Ping, Dong Li-Jun, Dong Min-Yue, Yang Xiao-Fu, Lu Xiu-E, Huang He-Feng
Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, 2 Xue Shi Road, Hangzhou, Zhejiang, 31006, China.
J Clin Endocrinol Metab. 2007 Dec;92(12):4771-6. Epub 2007 Sep 25.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
 
 
NIH criteria 
Related 
11 women with PCOS, 12 controls 
Genes involved in inflammation, lipid metabolism, and Wnt signaling are differentially expressed in nonobese PCOS adipose tissue. Because these genes are known to affect adipogenesis and insulin resistance, we hypothesize that their dysregulation may contribute to the metabolic abnormalities observed in women with PCOS 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26283014
miR-483-5p and miR-486-5p are down-regulated in cumulus cells of metaphase II oocytes from women with polycystic ovary syndrome. 
In vitro 
23603633
Differences in the transcriptional profiles of human cumulus cells isolated from MI and MII oocytes of patients with polycystic ovary syndrome. 
In vitro 

 

| © 2015, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412