SERPINF1

Gene Information
 
Gene Symbol
SERPINF1
 
Aliases
EPC-1, OI12, OI6, PEDF, PIG35
 
Entrez Gene ID
 
Gene Name
Serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
 
Chromosomal Location
17p13.3
 
HGNC ID
 
Summary
The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.(provided by RefSeq, Mar 2011)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007275 Biological process Multicellular organismal development TAS 8473338
GO:0008283 Biological process Cell proliferation TAS 8473338
GO:0016525 Biological process Negative regulation of angiogenesis IDA 11562499
GO:0050769 Biological process Positive regulation of neurogenesis IDA 8226833
GO:0005576 Cellular component Extracellular region IDA 12737624
Protein Information
 
Protein Name
Pigment epithelium-derived factor
 
Function
Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00079 Serpin Serpin (serine protease inhibitor)
 
OMIM

Associated Diseases

Diseases References
Insulin resistance 21209034
Polycystic ovary syndrome (PCOS) 21209034
   
References
 
Primary:

Serum pigment epithelium-derived factor is elevated in women with polycystic ovary syndrome and correlates with insulin resistance.

Yang Shumin, Li Qifu, Zhong Li, Song Ying, Tian Bo, Cheng Qingfeng, Qing Hua, Xia Wei, Luo Mei, Mei Mei
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Street, Chongqing 400016, China.
J Clin Endocrinol Metab. 2011 Mar;96(3):831-6. doi: 10.1210/jc.2010-2140. Epub
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
PCOS, Insulin resistance 
 
Rotterdam criteria 
Related 
96 PCOS women, 63 controls 
The serum PEDF level is elevated in women with PCOS and is associated with IR. PEDF may play a role in the pathogenesis of IR in PCOS 

 

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