RETN

Gene Information
 
Gene Symbol
RETN
 
Aliases
ADSF, FIZZ31, RSTN, XCP1, RETN
 
Entrez Gene ID
 
Gene Name
Resistin
 
Chromosomal Location
19p13.2
 
HGNC ID
 
Summary
This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein
Protein Information
 
Protein Name
Resistin
 
Function
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
Accessions
IPR009714
 
Pfam
Pfam Accession Pfam ID
PF06954 Resistin Resistin
 
OMIM
 
Phenotype MIM ID
 
Interactions
STRING MINT I2D
ENSP00000221515 Q9HD89

Associated Diseases

Diseases References
Acute pancreatitis 20485254, 20015433, 17295762, 17679375
Anorexia nervosa 16921786, 15598689, 16889937, 16173945, 18657008
Apnea sleep 15328483
Arthritis 16414972, 17040961, 15843582, 20346233, 17207388, 17998831, 18511473, 19095472, 18565254, 17040961, 16527497, 15843582, 19770005, 19022697, 17456023, 19095472, 20151765
Atherosclerosis 18710472, 15710760, 18023360, 16271710, 20221876, 17178123, 14733921, 16625816, 17998831, 20091460, 16313475, 16608899, 17175295, 16521924, 17383891, 17543176, 16159596, 18622895, 17498119, 17173885, 17067553, 15670203, 17366001, 20203628, 19262583, 19275676, 18654008, 20151765, 19105094, 17973945, 18257120, 17882987, 16227702, 16249281, 16173945, 19269054, 18997620, 17727677, 17877922, 18385536, 19740705, 19848317, 18723235, 16822679, 20106477, 17598818, 17384443
   
References
 
Primary:

The expression of resistin in adipose tissues of patients with polycystic ovary syndrome and insulin resistance.

Chu Yongli, Cui Qing, Feng Guijiao, Song Zhiyun, Jiang Xueqiang
Department of Obstetrics and Gynecology, Yantai Yuhuangding Hospital, Yantai, 264000, China. ccwish@163.com
J Huazhong Univ Sci Technolog Med Sci. 2009 Oct;29(5):642-5. Epub 2009 Oct 11.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
insulin resistance 
 
 
PCOS was defined by clinical, laboratory and ultrasound criteria.  
Related 
17 PCOS and 10 Control 
Overexpression of the resistin gene in adipocytes may be a local determinant factor in the pathogenesis of PCOS 
leptin and ghrelin 
 
 
 
Related 
28 PCOS and 19 control 
 
Adiponectin and Leptin 
 
 
 
Related 
87 PCOS and 67 Control 
 
 
 
 
 
Related 
281 womens  
 
IR 
 
 
 
Related 
 
Plasma resistin does not correlate with normal weight PCOS or IR. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26177495
Obesity and inflammatory biomarkers in women with polycystic ovary syndrome. 
Clinical study 
26051098
Validity of adiponectin-to-leptin and??adiponectin-to-resistin ratios as??predictors of polycystic ovary syndrome. 
Clinical study 
25377599
The impact of metformin treatment on adiponectin and resistin levels in women with polycystic ovary syndrome: a prospective clinical study. 
Effect of treatment 
25237319, PMC4166205
Visfatin and resistin serum levels in normal-weight and obese women with polycystic ovary syndrome. 
Clinical study 
25010619
Are insulin resistance and serum resistin levels increased in women with idiopathic hirsutism? 
Clinical study 

 

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