RBP4

Gene Information
 
Gene Symbol
RBP4
 
Aliases
MCOPCB10, RDCCAS
 
Entrez Gene ID
 
Gene Name
Retinol binding protein 4, plasma
 
Chromosomal Location
10q23.33
 
HGNC ID
 
Summary
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0030277 Biological process Maintenance of gastrointestinal epithelium IDA 10944490
GO:0032024 Biological process Positive regulation of insulin secretion IMP 16034410
GO:0032526 Biological process Response to retinoic acid IDA 571335
GO:0034633 Biological process Retinol transport IC 571335
GO:0042572 Biological process Retinol metabolic process IMP 10232633
Protein Information
 
Protein Name
Plasma retinol-binding protein(1-176)
 
Function
Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00061 Lipocalin Lipocalin / cytosolic fatty-acid binding protein family
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000360519 P02753

Associated Diseases

Diseases References
Albuminuria 12702785, 18973209, 19839150, 2250610, 9203174, 1756596
Alzheimers disease 18378077
Atherosclerosis 19846170, 19339013, 19486977, 19701163, 19114616
Cancer (carcinoma) 1649243
Cardiovascular diseases 17875187, 19339013, 19114616, 19766271, 17341558, 17890490, 18854400, 7735391, 18381580, 17970534
   
References
 
Primary:

Elevated serum RBP4 is associated with insulin resistance in women with polycystic ovary syndrome.

Weiping Li, Qingfeng Cheng, Shikun Ma, Xiurong Liu, Hua Qin, Xiaoshu Bai, Suhua Zhang, Qifu Li
Department of Endocrinology, First Affiliated Hospital, Chongqing Medical University, 1 Youyi Road, 400016, Chongqing, P. R. China.
Endocrine. 2006 Dec;30(3):283-7.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
PCOS 
 
 
Related 
50 PCOS, 40 controls 
The PCOS group showed higher RBP levels when compaired to the non-PCOS group and this difference may play an important role in the pathophysiology found in women with PCOS 
IR 
 
 
 
Related 
35 PCOS and 45 controls  
RBP4 and free plasma RBP4 expressed significantly lower in insulin-resistant PCOSsubjects in comparison to controls 
visfatin  
 
 
 
Related 
27 PCOS and 19 controls 
lean, glucose-tolerant women withPCOS have increased circulating visfatin and unaltered RBP4 concentrations compared with healthy 
Leptin and ADMA 
 
 
Rotterdam criteria 
Related 
57 PCOS and 27 controls 
PCOS have increased ADMA, RBP4, and leptin levels, and they are positively correlated with each other 
 
 
 
 
Related 
13 PCOS and 11 controls 
RBP4 may be involved in the dyslipidemia associated with PCOS 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25887459, PMC4414284
Polycystic ovarian syndrome is accompanied by repression of gene signatures associated with biosynthesis and metabolism of steroids, cholesterol and lipids. 
Animal study 
25371056
Retinol-binding protein 4, as a negative acute-phase reactant in polycystic ovary syndrome. 
Clinical study 
25069671
Association between retinol-binding protein 4 and polycystic ovary syndrome: a meta-analysis. 
Meta analysis 
23480783
Free fatty acid binding protein-4 and retinol binding protein-4 in polycystic ovary syndrome: response to simvastatin and metformin therapies. 
Effect of treatment 
23076844
Study of carbohydrate metabolism indices and adipocytokine profile and their relationship with androgens in polycystic ovary syndrome after menopause. 
Clinical study 

 

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