PYY

Gene Information
 
Gene Symbol
PYY
 
Aliases
PYY-I1, PYY
 
Entrez Gene ID
 
Gene Name
Peptide YY
 
Chromosomal Location
17q21.1
 
HGNC ID
 
Summary
The protein encoded by this gene is proteolytically processed to release a peptide that inhibits pancreatic secretion and mobility in the gut. Rare variations in this gene could increase susceptibility to obesity. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006928 Biological process Cellular component movement TAS 10488139
GO:0007010 Biological process Cytoskeleton organization TAS 7493937
GO:0007186 Biological process G-protein coupled receptor protein signaling pathway TAS 7592911
GO:0007267 Biological process Cell-cell signaling TAS 7493937
GO:0007586 Biological process Digestion TAS 7493937
Protein Information
 
Protein Name
Peptide YY(3-36)
 
Function
This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
Accessions
IPR001955, IPR020392
 
Pfam
Pfam Accession Pfam ID
PF00159 Hormone_3 Pancreatic hormone peptide
 
OMIM
 
Phenotype MIM ID
 
Interactions
STRING MINT I2D
ENSP00000353198 P10082

Associated Diseases

Diseases References
Atherosclerosis 18812636
Endothelial dysfunction 18812636
Low-grade chronic inflammation 18812636
Obesity 18812636
Pancreatic islet adaptation to insulin resistance 18812636
   
References
 
Primary:

Postprandial response of ghrelin and PYY and indices of low-grade chronic inflammation in lean young women with polycystic ovary syndrome.

Zwirska-Korczala K, Sodowski K, Konturek S J, Kuka D, Kukla M, Brzozowski T, Cnota W, Wozniak-Grygiel E, Jaworek J, Buldak R, Rybus-Kalinowska B, Fryczowski M
Department of Physiology, Zabrze, Medical University of Silesia, Katowice, Poland.
J Physiol Pharmacol. 2008 Aug;59 Suppl 2:161-78.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
GHRL,serum adiponectin,sCD40L,visfatin, sP-, sE-selectins, resistin 
Pancreatic islet adaptation to insulin resistance,low-grade chronic inflammation,endothelial dysfunction,atherosclerosis,obesity 
 
Rotterdam criteria 
Related 
 
The study provides the first evidence that lean untreated young PCOS women contribute to the so called "pancreatic islet adaptation to insulin resistance" because of ghrelin and PYY profiles.  

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26373789
Gastrointestinal hormone secretion in women with polycystic ovary syndrome: an observational study. 
Clinical study 
24001751
Basal and meal-stimulated ghrelin, PYY, CCK levels and satiety in lean women with polycystic ovary syndrome: effect of low-dose oral contraceptive. 
Effect of treatment 

 

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