PTX3

Gene Information
 
Gene Symbol
PTX3
 
Aliases
TNFAIP5, TSG-14
 
Entrez Gene ID
 
Gene Name
Pentraxin 3, long
 
Chromosomal Location
3q25
 
HGNC ID
 
Summary
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006954 Biological process Inflammatory response TAS 1429570
Protein Information
 
Protein Name
Pentraxin-related protein PTX3
 
Function
Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility (By similarity)
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00354 Pentaxin Pentaxin family
 
OMIM

Associated Diseases

Diseases References
Insulin resistance 22304663
   
References
 
Primary:

High plasma level of long Pentraxin 3 is associated with insulin resistance in women with polycystic ovary syndrome.

Aydogdu Aydogan, Tasci Ilker, Tapan Serkan, Basaran Yalcin, Aydogan Umit, Meric Coskun, Sonmez Alper, Aydogdu Sebnem, Akbulut Halil, Taslipinar Abdullah, Uckaya Gokhan, Azal Omer
Department of Endocrinology and Metabolism, Gulhane School of Medicine, Etlik, Ankara, Turkey. draydoganaydogdu@gmail.com
Gynecol Endocrinol. 2012 Sep;28(9):722-5. doi: 10.3109/09513590.2011.652719. Epub
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
hs-CRP 
Insulin resistance 
 
 
Related 
 
PTX3 level is increased in patients with PCOS in concordance with insulin resistance 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25419391, PMC4238465
Does low pentraxin-3 levels associate with polycystic ovary syndrome and obesity? 
Clinical study 
25300617
Disrupted hyaluronan binding protein 1 (HABP1) expression: one of the key mediator for ovarian dysfunction in polycystic ovary rat. 
Animal study 
25011417
Is pentraxin 3 a new cardiovascular risk marker in polycystic ovary syndrome? 
Clinical study 
24347428
Plasma levels of pentraxin-3, an inflammatory protein involved in fertility, are reduced in women with polycystic ovary syndrome. 
Clinical study 
24279306, PMC4222840
RUNX2, GPX3 and PTX3 gene expression profiling in cumulus cells are reflective oocyte/embryo competence and potentially reliable predictors of embryo developmental competence in PCOS patients. 
In vitro 

 

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