PROK1

Gene Information
 
Gene Symbol
PROK1
 
Aliases
EGVEGF, PK1, PRK1
 
Entrez Gene ID
 
Gene Name
Prokineticin 1
 
Chromosomal Location
1p21
 
HGNC ID
 
Summary
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein
Protein Information
 
Protein Name
Prokineticin-1
 
Function
Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis
 
Refseq Proteins
 
UniProt
 
InterPro
Accessions
IPR009523, IPR023569
 
Pfam
Pfam Accession Pfam ID
PF06607 Prokineticin Prokineticin
 
OMIM

Associated Diseases

Diseases References
Cancer (carcinoma) 15292351, 12538479
Cysts 12759245, 11528470
Polycystic ovary syndrome (PCOS) 14984768, 12759245
Preeclampsia 16384869
   
References
 
Primary:

EG-VEGF and Bv8: a novel family of tissue-restricted angiogenic factors.

Ferrara Napoleone, LeCouter Jennifer, Lin Rui, Peale Franklin
Department of Molecular Oncology, Genentech Inc, South San Francisco, CA 94080, USA. nf@gene.com
Biochim Biophys Acta. 2004 Mar 4;1654(1):69-78.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
 
 
 
Related 
 
EG-VEGF expression correlates with vascularity in the polycystic ovary syndrome, a leading cause of infertility. 
 
 
 
 
Direct 
13 human PCOS, 13 normal ovary specimens 
These findings indicate that both EG-VEGF and VEGF are expressed in PCOS ovaries, but in different cell types at different stages of differentiation 

 

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