PRL

Gene Information
 
Gene Symbol
PRL
 
Entrez Gene ID
 
Gene Name
Prolactin
 
Chromosomal Location
6p22.3
 
HGNC ID
 
Summary
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007166 Biological process Cell surface receptor linked signaling pathway TAS 10854700
GO:0007565 Biological process Female pregnancy NAS 7221563
GO:0008283 Biological process Cell proliferation TAS 10854700
GO:0040014 Biological process Regulation of multicellular organism growth IEP 8421089
GO:0005148 Molecular function Prolactin receptor binding TAS 10854700
Protein Information
 
Protein Name
Prolactin
 
Function
Prolactin acts primarily on the mammary gland by promoting lactation
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00103 Hormone_1 Somatotropin hormone family
 
KEGG
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000302150 P01236

Associated Diseases

Diseases References
Acromegaly 1574954, 8531896, 8127416, 15473133, 8706295, 10806816, 11318782, 2115046, 1715247, 10467911, 11078980, 11207632, 2262756, 8194638, 1341480, 1923946, 10913939, 1980333, 19509108, 19051037, 17242703, 11732393, 7969823, 17159821, 16932323, 8736275, 7746357, 7951491, 1823080, 14713276, 10776991, 9467544, 19890024, 19158203, 17546251, 12380732, 7594225, 8055814, 1395069, 1843271, 2058088, 17371464, 15141644, 10374130, 8778155, 8317187, 2272669, 1352308, 1356509, 8514980, 15765032, 16449338
Acth deficiency 10523016, 17162714, 1333997, 12717343
Anovulation 18393218, 1939525, 7900499, 12522680, 1838876, 11968579, 8521770, 18363281, 10962898, 9396291, 8540294, 9064619, 2125674
Cancer (adenoma) 8392915, 1910948, 14615416, 12713252, 1709764, 8246449, 8729534, 9689816, 7621567, 1353505, 9876339, 7559893, 7543115, 9591215, 8555361, 8386600, 2058088, 10633997, 8370706, 8449449, 8493775, 2234373, 1625993, 1334327, 9845004, 10426581, 12792878, 16410671, 15251697, 9413808, 7664668, 7913028, 7832831, 8511136, 1624729, 1665412, 19514648, 8109184, 8317187, 1571899, 1890464, 2291627, 2395335, 18633321, 18445999, 17308959, 9207961, 9004178, 8759496, 7623353, 8191626, 7903931, 8269424, 8395317, 7685856, 9410919, 8890999, 8763764, 8703557, 8245232, 1340555, 2042718, 18685288, 17556861, 11375124, 10374130, 11081197, 9666865, 16595604, 16216913, 15138537, 14971739, 12788890, 11965418, 10970071, 10487708, 1319562, 1742881, 18624930, 16914062, 17339401, 17242703, 15692944, 14528906, 12727930, 11972303, 11732393, 10601586, 9461321, 10806816, 9167961, 7627336, 16957766, 16505278, 15859156, 15257264, 14710344, 12644295, 12625413, , 2155694, 7951491, 8738481, 16926523, 11297766, 8759496, 1553037, 16932323, 8949563, 1625993, 8162255, 8890999, 1927271, 8493775, 8530610, 12660284, 1778242, 15803804, 1352308, 9790270, 11383480, 8392915, 12913700, 10943738, 10595830, 1500840, 20087113, 7858734, 2135789, 16883174, 14599121, 8317187, 10690891, 15185102, 9062514, 20106827, 9666878, 8246449, 10467911, 8191626, 1319562, 1789066, 18624930, 8964885, 2107017, 18633321, 11680511, 11081212, 11397894, 11231991, 10445280, 8834538, 1335954, 17524347, 17669717, 15181094, 14661732, 12746561, 11081197, 9833836, 9266438, 8418010, 10970071, 8769382, 8729527, 11740052, 11579683, 7543115, 8396420, 1928557, 2060147, 16226108, 10444306, 9932878, 9532003, 8669489, 8555361, 12165665, 11761722, 11685661, 2338572, 1285309, 1414153, 2272669, 7507690, 1709764, 1646081, 8475224, 9143002, 16199895, 16026128, 12011941, 11495005, 11482580, 10426581, 10366409, 10359139, 10350249, 15173951, 15070915, 14762579, 12528293, 12227947, 10971108, 10843153, 10487698, 9306123, 1789066, 11297766, 8875756, 2070893, 2114023, 18079591, 8769379, 15181094, 9876339, 10426581, 10426581, 24584638
Cancer (fibrous dysplasia polyostotic) 10517473, 7911814, 7962285
   
References
 
Primary:
PMID: 1916652

Evidence of altered dopaminergic modulation of prolactin and thyrotropin secretion in patients with polycystic ovary syndrome.

Velardo A, Pantaleoni M, Zironi C, Zizzo G, Marrama P
Department of Endocrinology, University of Modena, Italy.
Horm Res. 1991;35(1):4-7.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
INS  
TCM syndrome 
 
 
Related 
120 patients with PCOS were determined respectively, among them, 30 patients were classified by TCM syndrome 
Elevated level of T, LH and LH/FSH ratio, PRL and INS are correlated with the TCM syndrome type of SYiD, SYaD, GSH and PYD in patients with PCOS respectively, and being the clinical characteristics of the corresponding syndromes. 
 
Hyperprolactinemia  
 
 
Related 
224 women with PCOS and 30 women with hyperPRL + PCOS were compared 
Patients with hyperPRL + PCOS develop the endocrine disturbances at a younger age, a greater incidence rate of acne, level of prolactin and androstenedione, they have reduced ApoB and increased HOMA-IR. Patients' sisters with hyperPRL + PCOS have significantly greater incidence of acne, higher rates of infertility and PCOS as when compared with PCOS patients. 
 
 
 
 
Related 
hyperprolactinaemic patients and control group (healthy subjects) 
Diagnosis of hyperprolactinaemia should be associated with estimation of PRL biological activity because it is important for type of hyperprolactinaemia management. Low biological activity of PRL does not impair FSH and LH secretion and does not cause hypoestrogenism 
 
 
 
 
Related 
50patients were studied in the year 2005-06 in the outpatient department of Khyber  
Hormonal essays are mandatory in the evaluation of women presenting with Oligomenorhea/amenorrhea and chronic anovulatory infertility for finding out the cause and explaining the prognosis of the disease to the patient. 
Androgens and Cortisol  
 
 
Rotterdam criteria 
Related 
PCOS (n=8) and controls (n=7) 
Prolactin, androgens and cortisol might participate in alteration of insulin secretion in PCOS-affected women 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26314870, PMC4556163
Evaluation of Apelin and Insulin Resistance in Patients with PCOS and Therapeutic Effect of Drospirenone-Ethinylestradiol Plus Metformin. 
Effect of treatment 
26288423, PMC4533553
Correlation of Skin Changes with Hormonal Changes in Polycystic Ovarian Syndrome: A Cross-sectional Study Clinical Study. 
Clinical study 
26180527, PMC4477211
Leptin as well as Free Leptin Receptor Is Associated with Polycystic Ovary Syndrome in Young Women. 
Clinical study 
26165561
Hormonal and psychosocial correlates of psychological well-being and negative affectivity in young gynecological-endocrinological patients. 
Clinical study 
26152001
Exploring the significance of sex hormone-binding globulin examination in the treament of women with polycystic ovarian syndrome (PCOS). 
Effect of treatment 

 

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