PRDX2

Gene Information
 
Gene Symbol
PRDX2
 
Aliases
HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA
 
Entrez Gene ID
 
Gene Name
Peroxiredoxin 2
 
Chromosomal Location
19p13.2
 
HGNC ID
 
Summary
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. (provided by RefSeq, Mar 2013)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006979 Biological process Response to oxidative stress NAS 11904290
GO:0042744 Biological process Hydrogen peroxide catabolic process TAS 18606987
GO:0042981 Biological process Regulation of apoptotic process IMP 12943237
GO:0043066 Biological process Negative regulation of apoptotic process TAS 16130169
GO:0005737 Cellular component Cytoplasm TAS 16130169
Protein Information
 
Protein Name
Peroxiredoxin-2
 
Function
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00578 AhpC-TSA AhpC/TSA family
PF10417 1-cysPrx_C C-terminal domain of 1-Cys peroxiredoxin
 
OMIM

Associated Diseases

Diseases References
Diabetes mellitus type 2 23093701
Visceral adiposity 18156650
   
References
 
Primary:

Proteomic biomarkers of type 2 diabetes mellitus risk in women with polycystic ovary syndrome.

Galazis Nicolas, Afxentiou Thalia, Xenophontos Mikalena, Diamanti-Kandarakis Evanthia, Atiomo William
Division of Human Development, School of Clinical Sciences, Nottingham University Hospitals, University of Nottingham D Floor, East Block, Queens Medical Centre Campus, Nottingham NG7 2UH, UK. ngalazis@gmail.com
Eur J Endocrinol. 2013 Feb 1;168(2):R33-43. doi: 10.1530/EJE-12-0718. Print 2013
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
Pyruvate kinase M1/M2, apolipoprotein A-I, albumin, annexin A2, -1-B-glycoprotein, flotillin-1 and haptoglobin 
Insulin resistance and type 2 diabetes mellitus 
 
 
Related 
 
This study identified eight common biomarkers that were differentially expressed in both women with PCOS and T2DM when compared with healthy controls. These include pyruvate kinase M1/M2, apolipoprotein A-I, albumin, peroxiredoxin 2, annexin A2, 1-B-glycoprotein, flotillin-1 and haptoglobin. 
Proapolipoprotein Apo-A1, annexin V, glutathione S-transferase M3 (GSTM3), triosephosphate isomerase, peroxiredoxin 2 isoform a, actin and adipocyte plasma membrane-associated protein 
Visceral adiposity 
 
Presence of oligo-ovulation, clinical and/or biochemical hyperandrogenism, and exclusion of hyperprolactinemia, non-classic congenital adrenal hyperplasia and androgen-secreting tumors  
Related 
 
This preliminary study revealed differences in expression of proteins that may be involved in lipid and glucose metabolism, oxidative stress processes and adipocyte differentiation; they include proapolipoprotein Apo-A1, annexin V, glutathione S-transferase M3 (GSTM3), triosephosphate isomerase, peroxiredoxin 2 isoform a, actin and adipocyte plasma membrane-associated protein. 

 

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