PLAT

Gene Information
 
Gene Symbol
PLAT
 
Aliases
T-PA, TPA
 
Entrez Gene ID
 
Gene Name
Plasminogen activator, tissue
 
Chromosomal Location
8p12
 
HGNC ID
 
Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006464 Biological process Cellular protein modification process TAS 3087818
GO:0006508 Biological process Proteolysis TAS 3087818
GO:0031639 Biological process Plasminogen activation IDA 12694198
GO:0045861 Biological process Negative regulation of proteolysis IDA 1695900
GO:0005737 Cellular component Cytoplasm IDA 1632457
Protein Information
 
Protein Name
Alteplase, plasminogen activator, tissue type, plasminogen/activator kringle, reteplase, t-plasminogen activator, tissue plasminogen activator (t-PA)
 
Function
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration
 
Refseq Proteins
 
UniProt
 
InterPro
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Polycystic ovary syndrome (PCOS) 12107238, 20500107
   
References
 
Primary:

Matrix remodeling in the ovary: regulation and functional role of the plasminogen activator and matrix metalloproteinase systems.

Ny Tor, Wahlberg Patrik, Brandstrom Ida J M
Department of Medical Biochemistry and Biophysics, Umea University, S-90187, Ume, Sweden. tor.ny@medchem.umu.se
Mol Cell Endocrinol. 2002 Feb 22;187(1-2):29-38.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
Testosterone 
PCOS 
 
PCOS was defined as androgen excess (total testosterone >3.6 nmol/liter, or a free androgen index9) with ovulatory dysfunction (less than six menstrual cycles per year), once specific disorders such as adult onset congenital adrenal hyperplasia. 
Related 
Seventeen women with PCOS (defined on the basis of elevated testosterone and oligomenorrhea) and 15 healthy women  
 The study suggests that elevated t-PA and dysfibrinolysis may be a factor in the increased cardiovascular morbidity seen in PCOS. 
 
PCOS 
 
 
Related 
11 PCOS, 12 controls 
Women with the PCOS may have an imbalance in the plasminogen activator system that is tilted toward a reduced production of the proteolytic enzyme plasmin.  

 

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