PLA2G7

Gene Information
 
Gene Symbol
PLA2G7
 
Aliases
LDL-PLA2, LP-PLA2, PAFAD, PAFAH
 
Entrez Gene ID
 
Gene Name
Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
 
Chromosomal Location
6p21.2-p12
 
HGNC ID
 
Summary
 
GeneCards ID
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0034374 Biological process Low-density lipoprotein particle remodeling IDA 8624782
GO:0034440 Biological process Lipid oxidation IDA 8624782
GO:0034441 Biological process Plasma lipoprotein particle oxidation IDA 8624782
GO:0050729 Biological process Positive regulation of inflammatory response TAS 8624782
GO:0090026 Biological process Positive regulation of monocyte chemotaxis IDA 8624782
Protein Information
 
Protein Name
Platelet-activating factor acetylhydrolase
 
Function
Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
Accessions
IPR016715, IPR005065
 
Pfam
Pfam Accession Pfam ID
PF03403 PAF-AH_p_II isoform II
PF03403 PAF-AH_p_II Platelet-activating factor acetylhydrolase, isoform II
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Acute respiratory distress 12794395, 12626982, 15818104, 15187544
Allergic reaction 11916011
Anaphylaxis 18172172, 10708725, 18389523, 18389524, 18385504, 18589838
Arthritis juvenile rheumatoid 10025933
Asthma 10706731, 10194471, 8361018, 10733466, 10934081, 11916011, 16807087, 10051281, 15047169, 11535107
   
References
 
Primary:

Identification of the G994T polymorphism in exon 9 of plasma platelet-activating factor acetylhydrolase gene as a risk factor for polycystic ovary syndrome.

Fan Ping, Liu Hong-Wei, Wang Xiao-Su, Zhang Feng, Song Qi, Li Qin, Wu Hong-Mei, Bai Huai
Laboratory of Genetic Disease and Perinatal Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.
Hum Reprod. 2010 May;25(5):1288-94. Epub 2010 Feb 25.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
PCOS 
G994T 
Rotterdam criteria 
Related 
661 (346 Chinese Han women with PCOS and 315 Chinese Han controls) 
The G994T polymorphism in PAFAH gene may be one of the genetic determinants for PCOS in Chinese Han women 

 

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