PIK3R1

Gene Information
 
Gene Symbol
PIK3R1
 
Aliases
AGM7, GRB1, IMD36, p85, p85-ALPHA
 
Entrez Gene ID
 
Gene Name
Phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
 
Chromosomal Location
5q13.1
 
HGNC ID
 
Summary
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0014065 Biological process Phosphatidylinositol 3-kinase signaling IDA 7782332
GO:0046326 Biological process Positive regulation of glucose import ISS 8052599
GO:0048009 Biological process Insulin-like growth factor receptor signaling pathway IPI 7541045
GO:0060396 Biological process Growth hormone receptor signaling pathway IDA 7782332
GO:0090004 Biological process Positive regulation of establishment of protein localization to plasma membrane ISS 8052599
Protein Information
 
Protein Name
P85-ALPHA , PI3-kinase subunit p85-alpha , PtdIns-3-kinase regulatory subunit alpha , phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha , PI3K regulatory subunit alpha , phosphatidylinositol 3-kinase-associated p-85 alpha , PtdIns-3-kinase regulatory subunit p85-alpha , phosphoinositide-3-kinase, regulatory subunit 1 (alpha), phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) , PI3-kinase regulatory subunit alpha , phosphatidylinositol 3-kinase regulatory subunit alpha , GRB1 , Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha , ptdIns-3-kinase regulatory subunit alpha , p85
 
Function
Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00017 SH2 SH2 domain
PF00620 RhoGAP RhoGAP domain
PF07653 SH3_2 Variant SH3 domain
 
KEGG
ErbB signaling pathway, Chemokine signaling pathway, Phosphatidylinositol signaling system, mTOR signaling pathway, Apoptosis, VEGF signaling pathway, Osteoclast differentiation, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Leukocyte transendothelial migration, Neurotrophin signaling pathway, Cholinergic synapse, Regulation of actin cytoskeleton, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Type II diabetes mellitus, Aldosterone-regulated sodium reabsorption, Carbohydrate digestion and absorption, Bacterial invasion of epithelial cells, Chagas disease (American trypanosomiasis), Toxoplasmosis, Amoebiasis, Hepatitis C, Measles, Influenza A, Pathways in cancer, Colorectal cancer, Renal cell carcinoma, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Chronic myeloid leukemia, Acute myeloid leukemia, Small cell lung cancer, Non-small cell lung cancer
 
OMIM

Associated Diseases

Diseases References
Cancer (carcinoma) 16055672, 18260110
Niddm 15910625, 9032108, 12397383
Wiskott-aldrich syndrome 8824280, 11865026
   
References
 
Primary:

[Detection and significance of phosphatidylinositol 3-kinase in adipose tissue of polycystic ovary syndrome patients with insulin resistance].

Chu Yong-li, Qiu Hong-yu, Sun Yong-yu, Li Min, Li Hong-fa
Department of Obstetrics and Gynecology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhonghua Fu Chan Ke Za Zhi. 2006 Jul;41(7):455-8.

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25963796
Circulating gonadotropins and ovarian adiponectin system are modulated by acupuncture independently of sex steroid or ??-adrenergic action in a female hyperandrogenic rat model of polycystic ovary syndrome. 
Animal study 

 

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