PIBF1

Gene Information
 
Gene Symbol
PIBF1
 
Aliases
PIBF, CEP90, C13orf24
 
Entrez Gene ID
 
Gene Name
Progesterone immunomodulatory binding factor 1
 
Chromosomal Location
13q21.33
 
HGNC ID
 
Summary
Progesterone-induced-blocking factor 1
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007080 Biological process Mitotic metaphase plate congression IMP 21224392
GO:0010531 Biological process Activation of JAK1 kinase activity IDA 16393965
GO:0031393 Biological process Negative regulation of prostaglandin biosynthetic process IDA 3863495
GO:0032695 Biological process Negative regulation of interleukin-12 production IDA 14634107
GO:0032733 Biological process Positive regulation of interleukin-10 production IDA 14634107
Protein Information
 
Protein Name
Progesterone Immunomodulatory Binding Factor 1, Progesterone-Induced Blocking Factor 1, Progesterone-Induced-Blocking Factor 1, Chromosome 13 Open Reading Frame 24
 
Function
Mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling NK activity exerts an anti-abortive effect.
 
Refseq Proteins
 
UniProt
 
InterPro
Accessions
IPR026205
 
KEGG
 
OMIM

Associated Diseases

Diseases References
Polycystic ovary syndrome (PCOS) 12042261
   
References
 
Primary:

Luteal phase progesterone excretion in ovulatory women with polycystic ovaries.

Joseph-Horne Rosanne, Mason Helen, Batty Sari, White Davinia, Hillier Stephen, Urquhart Martha, Franks Stephen
Department of Reproductive Science and Medicine, Imperial College Faculty of Medicine, St Mary's Hospital, Paddington, London W2 1PG, UK.
Hum Reprod. 2002 Jun;17(6):1459-63.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
PCOS 
 
 
Related 
26 (10 infertile PCO, 10 infertile normal, 6 fertile normal) 
Women with PCO had significantly lower levels of progesterone in the early luteal phase than fertile women with normal ovaries. 

 

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