PGR

Gene Information
 
Gene Symbol
PGR
 
Aliases
NR3C3, PR
 
Entrez Gene ID
 
Gene Name
Progesterone receptor
 
Chromosomal Location
11q22-q23
 
HGNC ID
 
Summary
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. (provided by RefSeq, Jan 2011)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007165 Biological process Signal transduction TAS 1557371
GO:0007267 Biological process Cell-cell signaling TAS 1557371
GO:0043401 Biological process Steroid hormone mediated signaling pathway TAS 10840043
GO:0007165 Biological process Signal transduction TAS 1557371
GO:0007267 Biological process Cell-cell signaling TAS 1557371
Protein Information
 
Protein Name
Progesterone receptor
 
Function
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation| Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation| Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00104 Hormone_recep Ligand-binding domain of nuclear hormone receptor
PF00105 zf-C4 Zinc finger, C4 type (two domains)
PF02161 Prog_receptor Progesterone receptor
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Infertility 10682427
   
References
 
Primary:

[Pathological and immunohistochemical study on estrogen and progesterone receptors in endometrium of polycystic ovarian syndrome].

Li L, Yang C, Qiaojie
First Affiliated Hospital of Henan Medical University, Zhengzhou.
Zhonghua Fu Chan Ke Za Zhi. 1998 Feb;33(2):89-91.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
ER 
Infertility 
 
 
Related 
 
The endometrial histopathological changes and local decrease or absence of ER and PR in PCOS might be one of the causal factors of infertility. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26203175
A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. 
Animal study 
25750105, PMC4400200
Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro. 
In vitro 
25603724
Estrogen and progesterone receptor subtype expression in granulosa cells from women with polycystic ovary syndrome. 
In vitro 
25550522, PMC4299257
Enhancement of a robust arcuate GABAergic input to gonadotropin-releasing hormone neurons in a model of polycystic ovarian syndrome. 
Effect of treatment 
22956770
Human antral follicles <6 mm: a comparison between in vivo maturation and in vitro maturation in non-hCG primed cycles using cumulus cell gene expression. 
In vitro 

 

| © 2015, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412