PECAM1

Gene Information
 
Gene Symbol
PECAM1
 
Aliases
CD31, PECA1, GPIIA, PECAM-1, endoCAM, CD31/EndoCAM
 
Entrez Gene ID
 
Gene Name
Platelet/endothelial cell adhesion molecule 1
 
Chromosomal Location
17q23.3
 
HGNC ID
 
Summary
 
GeneCards ID
 
RefSeq mRNA
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006909 Biological process Phagocytosis IDA 12110892
GO:0007165 Biological process Signal transduction TAS 7994021
GO:0008037 Biological process Cell recognition TAS 1690453
GO:0050904 Biological process Diapedesis IDA 19342684
GO:0072011 Biological process Glomerular endothelium development IEP 17464107
Protein Information
 
Protein Name
Platelet/endothelial cell adhesion molecule , platelet endothelial cell adhesion molecule , endoCAM , PECAM-1 , CD31/EndoCAM , platelet/endothelial cell adhesion molecule 1, EndoCAM , PECA1 , CD31 , GPIIA' , CD31 antigen
 
Function
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF13895 Ig_2 Immunoglobulin domain
 
KEGG
 
OMIM

Associated Diseases

Diseases References
Endothelial dysfunction 22456311
Polycystic ovary syndrome (PCOS) 22456311
   
References
 
Primary:

Soluble platelet/endothelial cell adhesion molecule (sPECAM)-1 is increased in polycystic ovary syndrome and related to endothelial dysfunction.

Pepene Carmen Emanuela
Department of Endocrinology, University of Medicine and Pharmacy Cluj-Napoca, Romania. c_e_georgescu@yahoo.com
Gynecol Endocrinol. 2012 May;28(5):370-4. doi: 10.3109/09513590.2011.632792. Epub
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
Endothelial dysfunction 
 
 
Related 
 
Elevated sPECAM-1 contributes to endothelial dysfunction however further studies are inquired to assess its relevance as biomarker and potential therapeutic target in PCOS. 

 

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