PCOS1

Gene Information
 
Gene Symbol
PCOS1
 
Aliases
PCO, PCO1
 
Entrez Gene ID
 
Gene Name
Polycystic ovary syndrome 1
 
Chromosomal Location
19p13.2
 
HGNC ID
 
Summary
 
GeneCards ID
Protein
Protein Information
 
Protein Name
Polycystic ovary syndrome 1
 
Function
 
UniProt
 
OMIM
184700
 
Interactions
STRING MINT I2D

Associated Diseases

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Diseases References
Polycystic ovary syndrome (PCOS) 16091490
   
References
 
Primary:

Candidate gene region for polycystic ovary syndrome on chromosome 19p13.2.

Urbanek M, Woodroffe A, Ewens K G, Diamanti-Kandarakis E, Legro R S, Strauss J F 3rd, Dunaif A, Spielman R S
Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University School of Medicine, 303 East Chicago Avenue, Tarry 15-717, Chicago, Illinois 60611, USA. m-urbanek@northwestern.edu
J Clin Endocrinol Metab. 2005 Dec;90(12):6623-9. Epub 2005 Aug 9.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
 
 
Rotterdam criteria 
Direct 
367 families of predominantly European origin with at least one PCOS patient 
Linkage with PCOS was observed over a broad region of chromosome 19p13.2. The strongest evidence for association was observed with D19S884 (chi2 = 11.85; nominal P < 0.0006; permutation P = 0.034) and duplicated our earlier findings. 

Unreviewed Literature:

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PubMed / PMC ID
Title Type of study
24243639
No phenotypic differences for polycystic ovary syndrome (PCOS) between women with and without type 1 diabetes mellitus. 
 
22018827
Systemic inflammation, cellular influx and up-regulation of ovarian VCAM-1 expression in a mouse model of polycystic ovary syndrome (PCOS). 
 
16798272
PCOS (polycystic ovary syndrome): a multifaceted disease from adolescence to elderly. Proceedings of the second Special Scientific Meeting of the Androgen Excess Society. September 30-October 1, 2005. Ravello, Italy. 
 

 

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