NPY

Gene Information
 
Gene Symbol
NPY
 
Aliases
PYY4
 
Entrez Gene ID
 
Gene Name
Neuropeptide Y
 
Chromosomal Location
7p15.3
 
HGNC ID
 
Summary
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006816 Biological process Calcium ion transport TAS 8132547
GO:0006928 Biological process Cellular component movement TAS 10488139
GO:0007187 Biological process G-protein signaling, coupled to cyclic nucleotide second messenger TAS 8132547
GO:0007586 Biological process Digestion NAS 8421707
GO:0007610 Biological process Behavior TAS 9845072
Protein Information
 
Protein Name
C-flanking peptide of NPY
 
Function
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
Accessions
IPR001955, IPR020392
 
Pfam
Pfam Accession Pfam ID
PF00159 Hormone_3 Pancreatic hormone peptide
 
KEGG
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000242152 P01303

Associated Diseases

Diseases References
Alzheimers disease 8592643, 2209674, 11709213, 10841982
Anorexia nervosa 10923281, 17603492, 10207720, 9222646, 15855352, 17235527, 15331560, 15657373, 18812636, 22314079, 23685425, 22621829, 20504873, 21270326, 19240152, 17445806, 24040456, 22564702, 22575725, 23748472, 21853931, 22527903, 21827375, 20840271, 20130411, 20045799, 19549442, 18680073, 17141766, 16785159, 16600233, 16316841, 15853827, 15472214, 14671186, 12615821, 11836319, 19681917, 15717879, 15660727, 17420421, 7652727, 15208835, 16980199, 16334591, 18974244, 14764276, 17023708, 15159251, 9590566, 20001427, 19114407, 14976002, 9861517, 8462390, 1736105, 18309108, 17954428, 16506274, 14968294, 12627878, 18779682, 16581078, 9240771, 19138313, 16259222, 12957327, 16054467, 9100707, 17368007, 1457758, 7981184, 10707556, 9270410, 8856394, 12150695, 12692007, 19015938, 18775353, 18640389, 17873318, 17320517, 17183416, 17218834, 15998260, 15579783, 16820727, 16392771, 16319655, 14647894, 14553866, 11997182, 14739074, 12647277, 12408408, 12365467, 10821297, 10440591, 10374288, 8299479, 19149565, 7828781, 2065046, 19572942, 19421860, 19564534, 18927552, 18296327, 17826042, 17760500, 17259501, 16522281, 15075712, 12877091, 12702035, 12675638, 8949974, 19731182, 19164269, 17952838, 16839860, 15590982, 14626524, 12610050, 12540621, 12148078, 10024191, 8964200, 7782801, 20513276, 19369429, 19214921, 18772854, 16697386, 17181562, 15258201, 15047659, 8736268, 19218574, 17083810, 12042261, 9439531, 19947235, 11820995, 15073570, 18486583, 17119001, 17054989
Ascites 12754138, 11867178
Atherosclerosis 18812636
Autoimmunity 15364051, 17979783
   
References
 
Primary:

Neuropeptide Y, leptin, galanin and insulin in women with polycystic ovary syndrome.

Baranowska B, Radzikowska M, Wasilewska-Dziubinska E, Kaplinski A, Roguski K, Plonowski A
Neuroendocrinology Department, Medical Centre of Postgraduate Education, Warsaw, Poland.
Gynecol Endocrinol. 1999 Oct;13(5):344-51.

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26291814
Examination of angiopoietin-like protein 4, neuropeptide Y, omentin-1 levels of obese and non-obese patients with polycystic ovary syndrome. 
Clinical study 
26074346
Peptides: Basic determinants of reproductive functions. 
In vitro 
24905277
Innervation pattern of polycystic ovaries in the women. 
Clinical study 
22954591
Neuroendocrine control of female reproductive function by the activin receptor ALK7. 
In vitro 
22359978
Effect of short-term standard therapeutic regimens on neuropeptide Y and adipose tissue hormones in overweight insulin-resistant women with polycystic ovary syndrome. 
Effect of treatment 

 

| © 2015, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412