NPPB

Gene Information
 
Gene Symbol
NPPB
 
Aliases
BNP
 
Entrez Gene ID
 
Gene Name
Natriuretic peptide B
 
Chromosomal Location
1p36.2
 
HGNC ID
 
Summary
 
GeneCards ID
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006182 Biological process CGMP biosynthetic process IDA 1672777
GO:0007166 Biological process Cell surface receptor signaling pathway NAS 12727915
GO:0007168 Biological process Receptor guanylyl cyclase signaling pathway IDA 1672777
GO:0007589 Biological process Body fluid secretion TAS 14960748
GO:0008217 Biological process Regulation of blood pressure NAS 12727915
Protein Information
 
Protein Name
BNP(5-29)
 
Function
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
 
UniProt
 
PDB
 
InterPro
Accessions
IPR000663, IPR002408
 
Pfam
Pfam Accession Pfam ID
PF00212 ANP Atrial natriuretic peptide
 
OMIM

Associated Diseases

Diseases References
Cardiac risk 17855407
   
References
 
Primary:

Diagnostic potential of serum N-terminal pro-B-type brain natriuretic peptide level in detection of cardiac wall stress in women with polycystic ovary syndrome: a cross-sectional comparison study.

Celik Onder, Sahin Ibrahim, Celik Nilufer, Hascalik Seyma, Keskin Lezzan, Ozcan Hamdi, Uckan Ahmet, Kosar Feridun
Department of Obstetrics and Gynecology, Medical Faculty, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey. oncelik@inonu.edu.tr
Hum Reprod. 2007 Nov;22(11):2992-8. Epub 2007 Sep 12.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
Cardiac risk 
N-terminal pro-B-type BNP 
Rotterdam criteria 
Related 
 
The present study demonstrated that the level of NT-proBNP was increased in PCOS subjects with asymptomatic heart disease 

 

| © 2015, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412