NCOR1

Gene Information
 
Gene Symbol
NCOR1
 
Aliases
N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR
 
Entrez Gene ID
 
Gene Name
Nuclear receptor corepressor 1
 
Chromosomal Location
17p11.2
 
HGNC ID
 
Summary
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006366 Biological process Transcription from RNA polymerase II promoter TAS 7566114
GO:0046329 Biological process Negative regulation of JNK cascade IDA 11931768
GO:0051225 Biological process Spindle assembly IMP 18326024
GO:0072362 Biological process Regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter IMP 19955185
GO:0072368 Biological process Regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter IMP 19955185
Protein Information
 
Protein Name
KIAA1047 , nuclear receptor corepressor 1 , thyroid hormone- and retinoic acid receptor-associated corepressor 1 , N-CoR , N-CoR1 , nuclear receptor co-repressor 1 , hCIT529I10 , MGC104216 , TRAC1 , hN-CoR
 
Function
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00249 Myb_DNA-binding Myb-like DNA-binding domain
 
OMIM

Associated Diseases

Diseases References
Cancer (carcinoma) 14601091
Polycystic ovary syndrome (PCOS) 22349439
   
References
 
Primary:

A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells.

Qu Fan, Wang Fang-Fang, Yin Rong, Ding Guo-Lian, El-Prince Mohamed, Gao Qian, Shi Bi-Wei, Pan Hui-Hui, Huang Yi-Ting, Jin Min, Leung Peter C K, Sheng Jian-Zhong, Huang He-Feng
Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, Zhejiang, 310006, China.
J Mol Med (Berl). 2012 Aug;90(8):911-23. Epub 2012 Feb 21.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
 
 
 
Related 
 
Hyperandrogenism induces the epigenetic alterations of PPARG1, NCOR1, and HDAC3 in GCs, which are involved in the ovarian dysfunction of HA PCOS 

 

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