NAMPT

Gene Information
 
Gene Symbol
NAMPT
 
Aliases
1110035O14Rik, PBEF, PBEF1, VF, VISFATIN
 
Entrez Gene ID
 
Gene Name
Nicotinamide phosphoribosyltransferase
 
Chromosomal Location
7q22.3
 
HGNC ID
 
Summary
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006769 Biological process Nicotinamide metabolic process EXP 14704851
GO:0007165 Biological process Signal transduction TAS 8289818
GO:0007267 Biological process Cell-cell signaling TAS 8289818
GO:0008284 Biological process Positive regulation of cell proliferation TAS 8289818
GO:0008286 Biological process Insulin receptor signaling pathway IDA 17983582
Protein Information
 
Protein Name
Nicotinamide phosphoribosyltransferase
 
Function
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity)
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF04095 NAPRTase Nicotinate phosphoribosyltransferase (NAPRTase) family
 
KEGG
 
OMIM
 
Interactions

Associated Diseases

Diseases References
Atherosclerosis 10923281, 17603492, 10207720, 9222646, 15855352, 17235527, 15331560, 15657373, 18812636, 22314079, 23685425, 22621829, 20504873, 21270326, 19240152, 17445806, 24040456, 22564702, 22575725, 23748472, 21853931, 22527903, 21827375, 20840271, 20130411, 20045799, 19549442, 18680073, 17141766, 16785159, 16600233, 16316841, 15853827, 15472214, 14671186, 12615821, 11836319, 19681917, 15717879, 15660727, 17420421, 7652727, 15208835, 16980199, 16334591, 18974244, 14764276, 17023708, 15159251, 9590566, 20001427, 19114407, 14976002, 9861517, 8462390, 1736105, 18309108, 17954428, 16506274, 14968294, 12627878, 18779682, 16581078, 9240771, 19138313, 16259222, 12957327, 16054467, 9100707, 17368007, 1457758, 7981184, 10707556, 9270410, 8856394, 12150695, 12692007, 19015938, 18775353, 18640389, 17873318, 17320517, 17183416, 17218834, 15998260, 15579783, 16820727, 16392771, 16319655, 14647894, 14553866, 11997182, 14739074, 12647277, 12408408, 12365467, 10821297, 10440591, 10374288, 8299479, 19149565, 7828781, 2065046, 19572942, 19421860, 19564534, 18927552, 18296327, 17826042, 17760500, 17259501, 16522281, 15075712, 12877091, 12702035, 12675638, 8949974, 19731182, 19164269, 17952838, 16839860, 15590982, 14626524, 12610050, 12540621, 12148078, 10024191, 8964200, 7782801, 20513276, 19369429, 19214921, 18772854, 16697386, 17181562, 15258201, 15047659, 8736268, 19218574, 17083810, 12042261, 9439531, 19947235, 11820995, 15073570, 18486583, 17119001, 17054989, 17341558, 19501863, 16034410, 17656599, 17726085, 18081728, 18381580, 18487287, 17416795, 19537932, 19190263, 17595259, 19003725, 17550959, 18641048, 19501859, 17003346, 18783798, 17875187, 18493106, 18397979, 17721906, 17492427, 20037278, 18052678, 18426837, 18584408, 17970534, 18796616, 18334592, 17890490, 17640906, 19369430, 19264371, 17618858, 17065684, 19215278, 18710473, 17456573, 20222849, 18426814, 17411394, 19088257, 17337499, 18199128, 22397743, 15886251, 20889251, 22068557, 8671472, 11600878, 10418705, 2350207, 11460890, 15638873, 15820714, 20011249, 20406953, 23678035, 24743397, 22238371, 23979790, 16551740, 24969481, 1387563, 1742627, 1327496, 17204352, 11173902, 18050673, 9187410, 10695479, 16039281, 10648020, 16126968, 15311550, 18600083, 20205861, 11567663, 14995993, 11567664, 14678868, 8060375, 11278457, 12728597, 16477805, 15919609, 15380459, 14963283, 14553864, 10208482, 10064006, 9843166, 19918669, 17850750, 12871373, 15080492, 11733024, 11179976, 11129405, 10520809, 10364094, 10980830, 9498632, 14605330, 12911596, 12719278, 12734779, 12195702, 11816701, 11522017, 11373350, 10798278, 9041098, 9005966, 16789641, 15988701, 11092431, 11057874, 10831181, 9734732, 9423801, 9198234, 18501910, 15820196, 14746139, 12891381, 11372681, 10452346, 9622268, 18624608, 17161063, 16128865, 12911589, 11588944, 11525072, 10417403, 9805421, 9161416, 9258409, 19889809, 18559377, 18593221, 16427606, 15630497, 14993864, 9048903, 9031456, 8831916, 18191049, 17014002, 15901895, 15379715, 12921488, 7698502, 7813812, 8241103, 19888787, 19132219, 16939632, 16091487, 15575342, 12723974, 12540956, 11197396, 15516780, 9496335, 15588467, 15333250, 20201644, 15705377, 15598692, 12923954, 16421614, 16087989, 11753584, 16613757, 16757549, 18274928, 17076827, 15080783, 10657556, 16123358, 17892761, 11739453, 18571785, 17322479, 18437347, 12706940, 18220627, 17903275, 14680981, 19652658, 16839844, 16235156, 14698276, 17171553, 16029943, 15893251, 10416955, 19378424, 11445664, 11287357, 19543691, 19774846, 19375766, 15728208, 18319319, 9506738, 12029003, 12205025, 12660878, 12823641, 16550566, 16891032, 20216410, 20228013, 20148136, 19923378, 19875356, 19768241, 18946782, 16835332, 16773588, 18202591, 18253163, 17357288, 17167506, 17172321, 17027526, 16472051, 16567539, 16030153, 18339973, 18093792, 18239554, 18195475, 17267401, 17229078, 16464856, 15999465, 15978151, 15381186, 15181027, 12917504, 12778364, 12690081, 10422520, 20371668, 20131064, 20464701, 16891995, 15633587, 15561970, 20432261, 19875708, 20075410, 19436757, 19455721, 18953360, 18397542, 18923185, 15645209, 15294059, 14555603, 12898289, 12970313, 12734774, 11854119, 11225716, 19747414, 24628003, 2080142, 15024892, 18377903, 16409817, 12450312, 9286726, 16849416, 8871183, 8728917, 10764686, 16293162, 18175742, 15928193, 11681808, 9186610, 19672469, 15968580, 15780823, 15772559, 15297806, 10665338, 8673927, 11465242, 8355419, 15978107, 10102708, 20088250, 12884639, 1736034, 17046548, 10663216, 8589788, 11209987, 10845889, 19861967, 17896948, 15853833, 15356668, 12601637, 11719834, 10225688, 18083357, 18278185, 8633110, 11358950, 16735799, 9707262, 10546030, 10867719, 18154661, 18675814, 11383921, 10780314, 10631643, 10554079, 9361687, 8403825, 20118711, 17045221, 16990563, 15841306, 15634264, 9472456, 2070877, 17113660, 1772997, 20508843, 19700047, 19408737, 17991133, 17208662, 9308762, 1719559, 18037477, 18239151, 17704301, 17896947, 17912155, 15186635, 12536349, 9859722, 9133556, 16507937, 15869613, 15554360, 10527036, 10487691, 9539185, 9102176, 8843179, 16483878, 14694215, 18457598, 9869004, 16353333, 19106381, 19728971, 15168018, 11788625, 16710733, 20004425, 9275503, 15642079, 12212367, 16261187, 16956689, 9457008, 1541675, 7714116, 8299435, 17044662, 10450832, 9539195, 19828932, 19373236, 17652221, 11229419, 10513036, 8432411, 20150900, 11213538, 9717889, 1986032, 2229287, 18769626, 17087855, 1425092, 20034369, 16821208, 14627747, 17212015, 18394132, 9486987, 11145111, 11250769, 17430682, 16498800, 16444171, 15788447, 12739017, 9578244, 8910101, 8117866, 1999488, 18839419, 18413211, 12377756, 11344187, 11288039, 9550536, 7674911, 7738205, 20046661, 18172342, 18082417, 17300718, 1579553, 19837931, 19043735, 19361458, 17972239, 17589594, 18059082, 17613807, 17264235, 17264953, 16277579, 16225463, 15599552, 15579189, 15072732, 10337870, 7980344, 20156355, 18794246, 17986714, 17636091, 17613800, 17020651, 17166107, 15671910, 17075121, 15258344, 14678864, 16222595, 10900666, 20021721, 10895282, 10722859, 16782141, 15793852, 17147067, 17485319, 12519870, 15202616, 17005171, 12027912, 17878255, 11931523, 16129731, 16986526, 10612449, 16135472, 15070944, 10678256, 8621024, 18651469, 17721641, 12580939, 18805913, 17872473, 9618121, 20029268, 19112726, 20113633, 10228114, 8621025, 10102052, 10215564, 11812752, 10193869, 15533361, 11527094, 10395194, 9763877, 9357929, 9144295, 19851106, 17212381, 16344847, 15220914, 14735482, 12805397, 9342538, 9380811, 20058257, 16491055, 16419701, 15909762, 12582470, 11068094, 10333369, 20011966, 17026484, 15790575, 11824502, 9750463, 14655844, 17979776, 16441233, 11673768, 11271782, 11024570, 10997652, 10703535, 15481773, 19182739, 16105937, 14726256, 11795261, 10523013, 10603674, 15759020, 12605342, 9768648, 9747103, 19915520, 19949425, 16786731, 16522234, 15976687, 12420652, 11259650, 11172704, 11022201, 9924798, 9287057, 9202122, 9100610, 8892415, 14715846, 15910756, 23350621, 16452543, 11218147, 9711997, 9385530, 8923878, 21039282, 18692800, 17940109, 17583494, 16263811, 19351806, 19178507, 18663287, 20145358, 19834878, 17931620, 20151765, 20346149, 19940327, 19717018, 17378999, 19302375
Cancer 19109034, 20028851, 19936064, 18201551, 17052966, 17465726
Cardiovascular diseases 15968578, 16311222, 17970534, 16391616, 16674947, 20346149, 19485930, 20476950
Diabetes mellitus 15968578, 19727662, 20464702, 16311222, 18691043, 17261426, 16391616, 16674947, 17447161, 19284295, 19485930, 20476950
Endothelial dysfunction 18812636
   
References
 
Primary:

Plasma visfatin levels in normal weight women with polycystic ovary syndrome.

Panidis Dimitrios, Farmakiotis Dimitrios, Rousso David, Katsikis Ilias, Delkos Dimitrios, Piouka Athanasia, Gerou Spiros, Diamanti-Kandarakis Evanthia
Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Eur J Intern Med. 2008 Oct;19(6):406-12. Epub 2008 Jan 30.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
PYY,serum adiponectin,sCD40L,GHRL, sP-, sE-selectins, resistin 
Pancreatic islet adaptation to insulin resistance,low-grade chronic inflammation,endothelial dysfunction,atherosclerosis,obesity 
 
Rotterdam criteria 
Related 
 
The study provides the first evidence that lean untreated young PCOS women contribute to the so called "pancreatic islet adaptation to insulin resistance" because of ghrelin and PYY profiles. We confirmed existing of low-grade chronic inflammation in early stage of visceral obesity in lean PCOS patients. 
DHEA-S,17alpha-OH-progesterone,SHBG,PRL,Delta(4)-androstenedione 
Metabolic and hormonal disturbances,obesity 
 
 
Related 
25 PCOS, 24 overweight controls and 24 controls 
The present study indicates, for the first time, a possible involvement of increased visfatin levels in PCOS-associated metabolic and hormonal disturbances. 
Adiponectin and Leptin 
 
 
 
Related 
73 PCOS and 75 Control 
PCOS have high visfatin and leptin levels but low adiponectin levels 
 
PCOS 
 
 
Direct 
21 PCOS and 15 Controls 
The data indicates that plasma visfatin levels are associated with HDL-C and markers of hyperandrogenism, but it is not associated with proinflammatory markers and insulin resistance in lean women with PCOS 
RBP4 
 
 
 
Related 
27 PCOS and 19 control 
PCOS have increased circulating visfatin and unaltered RBP4 concentrations compared with healthy lean women 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25263366
[Effects of visfatin and metformin on insulin resistance and reproductive endocrine in rats with polycystic ovary syndrome]. 
Effect of treatment 
25102689
Spleen-yang-deficiency patients with polycystic ovary syndrome have higher levels of visfatin. 
Clinical study 
24943040
Expression and regulation of INTELECTIN1 in human granulosa-lutein cells: role in IGF-1-induced steroidogenesis through NAMPT. 
In vitro 
24576225
Correlation of visfatin levels and lipoprotein lipid profiles in women with polycystic ovary syndrome undergoing ovarian stimulation. 
Clinical study 
23076844
Study of carbohydrate metabolism indices and adipocytokine profile and their relationship with androgens in polycystic ovary syndrome after menopause. 
Clinical study 

 

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