MUC5AC

Gene Information
 
Gene Symbol
MUC5AC
 
Aliases
MUC5, TBM, leB, mucin
 
Entrez Gene ID
 
Gene Name
Mucin 5AC, oligomeric mucus/gel-forming
 
Chromosomal Location
11p15.5
 
HGNC ID
 
Summary
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0043206 Biological process Fibril organization IDA 10611155
GO:0043206 Biological process Extracellular fibril organization IDA 10611155
GO:0043205 Cellular component Fibril IDA 14749330
GO:0043205 Cellular component Fibril IDA 14749330
GO:0070062 Cellular component Extracellular vesicular exosome IDA 19199708
Protein Information
 
Protein Name
Gastric mucin, lewis B blood group antigen, major airway glycoprotein, mucin 5, subtypes A and C, tracheobronchial/gastric, mucin 5AC, oligomeric mucus/gel-forming pseudogene, mucin-5 subtype AC, tracheobronchial, tracheobronchial mucin
 
Function
Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system
 
UniProt
 
InterPro
 
OMIM

Associated Diseases

Diseases References
Ocular symptomatology 17362862
   
References
 
Primary:

Itchy-dry eye associated with polycystic ovary syndrome.

Bonini Stefano, Mantelli Flavio, Moretti Costanzo, Lambiase Alessandro, Bonini Sergio, Micera Alessandra
Interdisciplinary Center for Biomedical Research (CIR), Laboratory of Ophthalmology, University Campus Bio-Medico of Rome, Rome, Italy. s.bonini@unicampus.it
Am J Ophthalmol. 2007 May;143(5):763-771. Epub 2007 Mar 23.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
MUC1 
Ocular symptomatology 
 
 
Related 
 
Patients with PCOS had a significant reduction of the tear film BUT accompanied by a significant increase in goblet cell number and conjunctival MUC5AC messenger ribonucleic acid expression compared with both PCO patients and healthy subjects. 

 

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