MMP9

Gene Information
 
Gene Symbol
MMP9
 
Aliases
CLG4B, GELB, MANDP2, MMP-9
 
Entrez Gene ID
 
Gene Name
Matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
 
Chromosomal Location
20q12-q13
 
HGNC ID
 
Summary
 
GeneCards ID
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006508 Biological process Proteolysis IDA 2551898
GO:0030225 Biological process Macrophage differentiation TAS 2251898
GO:0051549 Biological process Positive regulation of keratinocyte migration IMP 17704059
GO:0005615 Cellular component Extracellular space IDA 2251898
GO:0004222 Molecular function Metalloendopeptidase activity IDA 16192646
Protein Information
 
Protein Name
82 kDa matrix metalloproteinase-9
 
Function
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.
 
UniProt
 
PDB
 
Pfam
Pfam Accession Pfam ID
PF00040 fn2 Fibronectin type II domain
PF00045 Hemopexin Hemopexin
PF00413 Peptidase_M10 Matrixin
PF01471 PG_binding_1 Putative peptidoglycan binding domain
PF04886 PT PT repeat
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Atherothrombosis 23249695
Chronic low-grade inflammation 23249695
Follicular atresia 11279294
Hyperandrogenism 23249695
Polycystic ovary syndrome (PCOS) 21437624, 20555001, 12620479, 11279294
   
References
 
Primary:

Glucose ingestion stimulates atherothrombotic inflammation in polycystic ovary syndrome.

Gonzalez Frank, Kirwan John P, Rote Neal S, Minium Judi
Dept. of Obstetrics and Gynecology, Indiana Univ. School of Medicine, AOC Rm. 6046, 550 N. Univ. Blvd., Indianapolis, IN 46202, USA. gonzalef@iupui.edu
Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E375-83. doi:
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
MMP-2 and TIMP-1 
Follicular atresia, formation of multiple ovarian cysts 
 
endocrine profile and ultrasonographic criteria 
Related 
 
A time-dependent increase in the production of MMP-9 was observed in cells from both normal and PCOS women, although the increase was more pronounced in the latter.  
NGAL,estradiol, androgens, C-reactive protein 
Vascular remodeling and plaque instability 
 
 
Related 
 
These findings indicate that NGAL and MMP-9/NGAL complex, two molecules that activate atherotic plaque erosion, is in lower concentrations in PCOS subjects. 
TIMP-1 
 
 
endocrine profile and ultrasonographic criteria 
Related 
 
In this preliminary study, similar and divergent patterns have emerged in the regulation of MMP-9 and TIMP-1 in human luteinized granulosa cells. Repressing MMP-9-TIMP-1 ratio may have an important modulatory effect on progesterone secretion. 
MMP-2, TIMP-1 
Cardiovascular risk,menstrual irregularities 
 
Rotterdam criteria 
Related 
 
Obese women with PCOS have elevated serum concentrations of MMP-2 and -9. 
MMP-2, TIMP-1, TIMP-2 
 
 
 
Related 
 
Significantly higher levels of MMP-2 and MMP-9 (p=0.02 and p<0.001, respectively) as well as TIMP-2 and TIMP-1 (p=0.006 and p<0.001, respectively) were found in the PCOS group compared to controls. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26203177
LH-Induced Steroidogenesis in the Mouse Ovary, but Not Testis, Requires Matrix Metalloproteinase 2- and 9-Mediated Cleavage of Upregulated EGF Receptor Ligands. 
Animal study 
25300617
Disrupted hyaluronan binding protein 1 (HABP1) expression: one of the key mediator for ovarian dysfunction in polycystic ovary rat. 
Animal study 

 

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