MMP26

Gene Information
 
Gene Symbol
MMP26
 
Entrez Gene ID
 
Gene Name
Matrix metallopeptidase 26
 
Chromosomal Location
11p15
 
HGNC ID
 
Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein degrades type IV collagen, fibronectin, fibrinogen, casein, vitronectin, alpha 1-antitrypsin, alpha 2-macroglobulin, and insulin-like growth factor-binding protein 1, and activates MMP9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006508 Biological process Proteolysis NAS 10987280
GO:0005578 Cellular component Proteinaceous extracellular matrix NAS 10801841
Protein Information
 
Protein Name
OTTHUMP00000069244 , Endometase , Matrilysin-2 , matrix metalloproteinase 26 , endometase , matrix metalloproteinase-26 , MMP-26 , MGC126592 , matrilysin 2 , matrix metallopeptidase 26, MGC126590 , matrilysin-2 , EC 3.4.24.-
 
Function
May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activates progelatinase B
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00413 Peptidase_M10 Matrixin
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000300762 Q9NRE1

Associated Diseases

Diseases References
Cancer (carcinoma) 19818727, 12798711, 15006646, 11389678, 11931652, 19895737, 15333466, 15816845, 17176253
Polycystic ovary syndrome (PCOS) 18765015, 17673039
   
References
 
Primary:

Microarray evaluation of endometrial receptivity in Chinese women with polycystic ovary syndrome.

Qiao Jie, Wang Lina, Li Rong, Zhang Xiaowei
Reproductive Medicine Centre, Peking University Third Hospital, Beijing 100083, China.
Reprod Biomed Online. 2008 Sep;17(3):425-35.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
TM4SF4 
 
 
 
Related 
21,571 genes were screened using microarray 
MMP26 was found to bedecreased during the implantation window in patients with PCOS 
 
 
 
 
Related 
7 normal and 9 pcos womens 
lower expression of MMP-26 in implantation window time in patients with PCOS than in normal patients 

 

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