MMP2

Gene Information
 
Gene Symbol
MMP2
 
Aliases
CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1
 
Entrez Gene ID
 
Gene Name
Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
 
Chromosomal Location
16q13-q21
 
HGNC ID
 
Summary
 
GeneCards ID
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006508 Biological process Proteolysis TAS 2834383
GO:0043231 Cellular component Intracellular membrane-bounded organelle IDA 18029348
GO:0005615 Cellular component Extracellular space IDA 18492766
GO:0005515 Molecular function Protein binding IPI 15146192
Protein Information
 
Protein Name
PEX
 
Function
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14 PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways
 
UniProt
 
PDB
 
Pfam
Pfam Accession Pfam ID
PF00040 fn2 Fibronectin type II domain
PF00045 Hemopexin Hemopexin
PF00413 Peptidase_M10 Matrixin
PF01471 PG_binding_1 Putative peptidoglycan binding domain
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Atherothrombosis 23249695
Chronic low-grade inflammation 23249695
Follicular atresia 11279294
Hyperandrogenism 23249695
Polycystic ovary syndrome (PCOS) 21437624, 20555001, 11279294
   
References
 
Primary:

Glucose ingestion stimulates atherothrombotic inflammation in polycystic ovary syndrome.

Gonzalez Frank, Kirwan John P, Rote Neal S, Minium Judi
Dept. of Obstetrics and Gynecology, Indiana Univ. School of Medicine, AOC Rm. 6046, 550 N. Univ. Blvd., Indianapolis, IN 46202, USA. gonzalef@iupui.edu
Am J Physiol Endocrinol Metab. 2013 Feb 15;304(4):E375-83. doi:
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
MMP-9 and TIMP-1 
Follicular atresia, formation of multiple ovarian cysts 
 
 
Related 
 
Thus the MMP-TIMP balance is shifted toward greater MMP activity in luteinized granulosa cells from women with PCOS 
MMP-9, TIMP-1 
Cardiovascular risk,menstrual irregularities 
 
Rotterdam criteria 
Related 
 
Obese women with PCOS have elevated serum concentrations of MMP-2 and -9. 
MMP-9, TIMP-1, TIMP-2 
 
 
 
Related 
 
Significantly higher levels of MMP-2 and MMP-9 were found in the PCOS group compared to controls.  
MMP-8, MMP-9, TIMP-1, TIMP-2 
 
 
 
Related 
 
We found higher MMP-2/TIMP-2 and MMP-9/TIMP-1 ratios in PCOS patients than in healthy controls  
AP-1,EGR-1,TF 
Chronic low-grade inflammation,atherothrombosis,hyperandrogenism 
 
Rotterdam criteria 
Related 
 
Lean women with PCOS exhibited greater AP-1 activation and MMP2 protein content after glucose ingestion and higher plasma MMP9 and CRP levels than lean controls 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26203177
LH-Induced Steroidogenesis in the Mouse Ovary, but Not Testis, Requires Matrix Metalloproteinase 2- and 9-Mediated Cleavage of Upregulated EGF Receptor Ligands. 
Animal study 
25750105, PMC4400200
Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro. 
In vitro 
25300617
Disrupted hyaluronan binding protein 1 (HABP1) expression: one of the key mediator for ovarian dysfunction in polycystic ovary rat. 
Animal study 

 

| © 2015, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412