MMP1

Gene Information
 
Gene Symbol
MMP1
 
Aliases
CLG, CLGN
 
Entrez Gene ID
 
Gene Name
Matrix metallopeptidase 1 (interstitial collagenase)
 
Chromosomal Location
11q21-q22
 
HGNC ID
 
Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.(provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006508 Biological process Proteolysis TAS 2167156
GO:0004222 Molecular function Metalloendopeptidase activity IDA 9920899
Protein Information
 
Protein Name
27 kDa interstitial collagenase
 
Function
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00045 Hemopexin Hemopexin
PF00413 Peptidase_M10 Matrixin
PF01471 PG_binding_1 Putative peptidoglycan binding domain
 
KEGG
 
OMIM
 
Phenotype MIM ID
 
Interactions
STRING MINT I2D
ENSP00000322788 P03956

Associated Diseases

Diseases References
Aortic aneurysm 16122719, 8412067, 18226564, 18641692, 19886986
Arthritis 12010565, 10334680, 11665967, 12447637, 11908571, 9512498, 15743480, 16688934, 12447637, 15292813, 8849537, 12509618, 11259586, 15618147, 15102798, 18802702, 14523226
Arthropathy 9972954, 16688934
Atherosclerosis 19951575, 19156230, 12697757, 15034206, 8774133, 15073384, 15621056, 11866921, 7664418, 17268019, 18218585
Cancer (carcinoma) 11007031, 8766524, 11161388, 19480010
   
References
 
Primary:

A polymorphism in the matrix metalloproteinase-1 gene promoter is associated with the presence of polycystic ovary syndrome in Caucasian women.

Walch Katharina, Nagele Friedrich, Zeillinger Robert, Vytiska-Binstorfer Elisabeth, Huber Johannes C, Hefler Lukas A
Department of Obstetrics and Gynecology, Medical University Vienna, Vienna, Austria. katharina.walch@meduniwien.ac.at
Fertil Steril. 2005 May;83(5):1565-7.

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
26203177
LH-Induced Steroidogenesis in the Mouse Ovary, but Not Testis, Requires Matrix Metalloproteinase 2- and 9-Mediated Cleavage of Upregulated EGF Receptor Ligands. 
In vitro 
25750105, PMC4400200
Endometrial stromal fibroblasts from women with polycystic ovary syndrome have impaired progesterone-mediated decidualization, aberrant cytokine profiles and promote enhanced immune cell migration in vitro. 
In vitro 

 

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