MIF

Gene Information
 
Gene Symbol
MIF
 
Aliases
GIF, GLIF, MMIF
 
Entrez Gene ID
 
Gene Name
Macrophage migration inhibitory factor (glycosylation-inhibiting factor)
 
Chromosomal Location
22q11.23
 
HGNC ID
 
Summary
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0001516 Biological process Prostaglandin biosynthetic process IDA 12782713
GO:0007166 Biological process Cell surface receptor linked signaling pathway IDA 12782713
GO:0008283 Biological process Cell proliferation IDA 12782713
GO:0010629 Biological process Negative regulation of gene expression IDA 10562313
GO:0010739 Biological process Positive regulation of protein kinase A signaling cascade IDA 17045821
Protein Information
 
Protein Name
Macrophage migration inhibitory factor
 
Function
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF01187 MIF Macrophage migration inhibitory factor (MIF)
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Acute pancreatitis 16574946, 17245183, 17495357, 20397261, 12612911
Acute respiratory distress 9055860, 9430786, 16237655
Aggressiveness 12218292, 11568623, 12748256, 19128232
Allergic reaction 1937921, 8551232, 11773885, 12165273, 9535548
Alzheimers disease 15468912, 20200619
   
References
 
Primary:

First evidence of genetic association between the MIF-173G/C single-nucleotide polymorphisms and polycystic ovary syndrome.

Li Chao, Qiao Binglong, Zhan Ying, Qi Weihong, Chen Zi-Jiang
Department of Obstetrics and Gynecology, Affiliated Hospital of Medical College of Qingdao University, Shandong, China.
Am J Reprod Immunol. 2011 Nov;66(5):416-22. doi:
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
MCP-1,MIP-1alpha 
Insulin resistance, abdominal obesity and low-grade inflammation 
 
 
Related 
 
The data suggests a fat mass independent association between testosterone and MIF levels in PCOS and the effect of anti-androgen treatment on chemokine levels needs to be examine 
 
 
MIF-173G/C polymorphism 
 
Related 
Han Chinese-529 PCOS and 585 controls 
The MIF-173G/C polymorphism is associated with PCOS in Chinese Han women and may contribute to the phenotypic expression of PCOS. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25458401
Macrophage migration inhibitory factor in obese and non obese women with polycystic ovary syndrome. 
Clinical study 
25446648, PMC4429000
Higher circulating leukocytes in women with PCOS is reversed by aerobic exercise. 
Clinical study 

 

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