LPL

Gene Information
 
Gene Symbol
LPL
 
Aliases
HDLCQ11, LIPD
 
Entrez Gene ID
 
Gene Name
Lipoprotein lipase
 
Chromosomal Location
8p22
 
HGNC ID
 
Summary
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. (provided by RefSeq, Jul 2008)
 
GeneCards ID
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006641 Biological process Triglyceride metabolic process ISS 10727238
GO:0006644 Biological process Phospholipid metabolic process ISS 10727238
GO:0010744 Biological process Positive regulation of macrophage derived foam cell differentiation IC 12573449
GO:0010886 Biological process Positive regulation of cholesterol storage IMP 12573449
GO:0010890 Biological process Positive regulation of sequestering of triglyceride IMP 12573449
Protein Information
 
Protein Name
Lipoprotein lipase
 
Function
The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity)
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00151 Lipase Lipase
PF01477 PLAT PLAT/LH2 domain
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Hyperandrogenism 21084397
   
References
 
Primary:

Adipose tissue has aberrant morphology and function in PCOS: enlarged adipocytes and low serum adiponectin, but not circulating sex steroids, are strongly associated with insulin resistance.

Manneras-Holm Louise, Leonhardt Henrik, Kullberg Joel, Jennische Eva, Oden Anders, Holm Goran, Hellstrom Mikael, Lonn Lars, Olivecrona Gunilla, Stener-Victorin Elisabet, Lonn Malin
Institute of Neuroscience and Physiology, Department of Physiology, Sahlgrenska Academy, University of Gothenburg, SE-405 30 Gothenburg, Sweden.
J Clin Endocrinol Metab. 2011 Feb;96(2):E304-11. doi: 10.1210/jc.2010-1290. Epub
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
SHBG,adiponectin 
Hyperandrogenemia 
 
Rotterdam criteria 
Related 
 
Comparison of 31 pairs revealed lower insulin sensitivity, hyperandrogenemia, and higher free 17-estradiol in PCOS. Abdominal adipose tissue volumes/distribution did not differ in the groups, but PCOS women had higher waist-to-hip ratio, enlarged adipocytes, reduced adiponectin, and lower LPL activity. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
22154367
Effects of acupuncture and exercise on insulin sensitivity, adipose tissue characteristics, and markers of coagulation and fibrinolysis in women with polycystic ovary syndrome: secondary analyses of a randomized controlled trial. 
Effect of treatment 

 

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