LPA

Gene Information
 
Gene Symbol
LPA
 
Aliases
AK38, APOA, LP
 
Entrez Gene ID
 
Gene Name
Lipoprotein, Lp(a)
 
Chromosomal Location
6q25-q26
 
HGNC ID
 
Summary
The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. (provided by RefSeq, Dec 2009)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006629 Biological process Lipid metabolic process NAS 8047165
GO:0008015 Biological process Blood circulation TAS 8047165
GO:0010951 Biological process Negative regulation of endopeptidase activity TAS 8047165
GO:0034358 Cellular component Plasma lipoprotein particle IDA 2531657
GO:0001968 Molecular function Fibronectin binding IPI 2531657
Protein Information
 
Protein Name
Apolipoprotein(a)
 
Function
Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00051 Kringle Kringle domain
PF00089 Trypsin Trypsin
 
OMIM

Associated Diseases

Diseases References
Atherosclerosis 10593369
Cardiovascular diseases 22703625, 16019370
Dyslipidemia 22703625
Endothelial dysfunction 22703625
Hyperandrogenism 11720200, 9329374
   
References
 
Primary:

[Effect of hyperprolactinemia upon clinical symptoms of patients with polycystic ovary syndrome].

Wang Ying, Hu Zhi-ping, Li Mei-zhi, Li Rong, Wang Li-na, Chen Xin-na, Yang Chi-sun, Qiao Jie
Reproductive Medical Center, Peking University Third Hospital, Beijing 100191, China.
Zhonghua Yi Xue Za Zhi. 2009 Oct 13;89(37):2599-603.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
ApoB 
Hyperandrogenemia,dyslipidemia and obesity 
 
 
Related 
 
The study confirms the trend toward dyslipidemia among women with PCOS, particularly in parameters associated with cardiovascular risk 
 
Androgen excess and insulin resistance. 
 
 
Related 
 
The data suggest that altered lipid profiles in women with PCOS may result from the independent effects of androgen excess and insulin resistance 
Granulosa cell biomarker 
 
 
 
Related 
 
This study suggests that ApoA-I can be useful as a granulosa cell biomarker of PCOS patients and that downregulated ApoA-I may be related to the disturbed production of steroid hormones in PCOS patients. 
Lipoprotein phenotype B 
Atherosclerosis 
 
NIH criteria 
Related 
Hispanic women-16 PCOS & 21 controls 
Hispanic women may have a higher incidence of the atherogenic lipoprotein phenotype B, which may increase their risk for atherosclerosis 
APOB 
Dyslipidemia,obesity, insulin resistance, and hyperandrogenemia 
 
Rotterdam criteria 
Related 
 
When age, BMI, free androgen index, insulin sensitivity determined by all methods, and the presence of PCOS were subjected to stepwise multivariate regression analysis, the presence of PCOS was the most consistent predictor of lipid-depleted HDL (HDL total cholesterol/apoA-I and HDL phospholipids/apoA-I) 

 

| © 2015, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412