LOX

Gene Information
 
Gene Symbol
LOX
 
Entrez Gene ID
 
Gene Name
Lysyl oxidase
 
Chromosomal Location
5q23.3-q31.2
 
HGNC ID
 
Summary
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006464 Biological process Protein modification process TAS 1685472
Protein Information
 
Protein Name
Protein-lysine 6-oxidase
 
Function
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression
 
Refseq Proteins
 
UniProt
 
InterPro
Accessions
IPR001695, IPR019828
 
Pfam
Pfam Accession Pfam ID
PF01186 Lysyl_oxidase Lysyl oxidase
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000231004 P28300

Associated Diseases

Diseases References
Amyotrophic lateral sclerosis 14741400
Cancer 17471532, 11201293, 17943411, 8564968
Cardiovascular diseases 18469024, 17981747, 12417550, 18560621
Liver diseases 16023247
Menkes disease 1975662, 8980283, 12838205
   
References
 
Primary:

Lysyl oxidase interacts with AGE signalling to modulate collagen synthesis in polycystic ovarian tissue.

Papachroni Katerina K, Piperi Christina, Levidou Georgia, Korkolopoulou Penelope, Pawelczyk Leszek, Diamanti-Kandarakis Evanthia, Papavassiliou Athanasios G
Department of Biological Chemistry, Medical School, University of Athens, Athens, Greece.
J Cell Mol Med. 2010 Oct;14(10):2460-9. doi: 10.1111/j.1582-4934.2009.00841.x.

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25550522, PMC4299257
Enhancement of a robust arcuate GABAergic input to gonadotropin-releasing hormone neurons in a model of polycystic ovarian syndrome. 
In vitro 

 

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