LIPE

Gene Information
 
Gene Symbol
LIPE
 
Aliases
AOMS4, FPLD6, HSL, LHS
 
Entrez Gene ID
 
Gene Name
Lipase, hormone-sensitive
 
Chromosomal Location
19q13.1-q13.2
 
HGNC ID
 
Summary
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. (provided by RefSeq, Jul 2008)
 
GeneCards ID
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006468 Biological process Protein phosphorylation TAS 3420405
GO:0005515 Molecular function Protein binding IPI 17026959
Protein Information
 
Protein Name
Hormone-sensitive lipase
 
Function
In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF06350 HSL_N Hormone-sensitive lipase (HSL) N-terminus
PF07859 Abhydrolase_3 alpha/beta hydrolase fold
 
KEGG
 
OMIM

Associated Diseases

Diseases References
Dyslipidemia 11298776
Niddm 15609025, 8692022, 9519728
   
References
 
Primary:

Omental adipose tissue overexpression of fatty acid transporter CD36 and decreased expression of hormone-sensitive lipase in insulin-resistant women with polycystic ovary syndrome.

Seow Kok-Min, Tsai Yieh-Loong, Hwang Jiann-Loung, Hsu Wei-Yen, Ho Low-Tone, Juan Chi-Chang
Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Hum Reprod. 2009 Aug;24(8):1982-8. Epub 2009 May 7.

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
21147223
Expression of 11??-hydroxysteroid dehydrogenase type 1 in visceral and subcutaneous adipose tissues of patients with polycystic ovary syndrome is associated with adiposity. 
In vitro 

 

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