LIPC

Gene Information
 
Gene Symbol
LIPC
 
Aliases
HDLCQ12, HL, HTGL, LIPH
 
Entrez Gene ID
 
Gene Name
Lipase, hepatic
 
Chromosomal Location
15q21-q23
 
HGNC ID
 
Summary
LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. (provided by RefSeq)
 
GeneCards ID
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0006633 Biological process Fatty acid biosynthetic process IDA 182536
GO:0019433 Biological process Triglyceride catabolic process IDA 182536
GO:0034372 Biological process Very-low-density lipoprotein particle remodeling IDA 8640403
GO:0034373 Biological process Intermediate-density lipoprotein particle remodeling TAS 2839510
GO:0034374 Biological process Low-density lipoprotein particle remodeling IMP 3244012
Protein Information
 
Protein Name
Hepatic triacylglycerol lipase
 
Function
Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin
 
Refseq Proteins
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00151 Lipase Lipase
PF01477 PLAT PLAT/LH2 domain
 
KEGG
 
OMIM
 
Phenotype MIM ID
 
Interactions
STRING MINT I2D
ENSP00000299022 P11150

Associated Diseases

Diseases References
Atherosclerosis 15205216, 18599739, 12235167, 9645503, 9081692, 10077457, 15755868, 7853704, 14505482, 11395034, 15284087, 16397139, 15296699, 1883393, 1671786, 12401876, 10946021, 10937353, 8123642, 8485124, 17440012, 16603721, 12609972, 12642787, 19558527, 9711993, 11971936, 15565512, 11923122, 10064724, 14651331, 17537154, 1301939, 9974411, 10882343, 16822236, 10431662, 10729390, 12642787
Calcification 16141008
Cardiovascular diseases 19088157, 12642787, 7583564, 12691171, 17440012, 19349471, 19052449, 15817871, 11454011, 8808756
Diabetes mellitus insulin-dependent 8728871, 8062608
Hyperlipidemia 9885775, 2297346, 1301939, 10559017, 10511296, 18724972, 19528346, 17137217, 1968704
   
References
 
Primary:

Lipids and lipoprotein subfractions in women with PCOS: relationship to metabolic and endocrine parameters.

Pirwany I R, Fleming R, Greer I A, Packard C J, Sattar N
Department of Obstetrics and Gynaecology, Glasgow Royal Infirmary University NHS Trust, Glasgow, UK. imran.pirwany@muhc.mcgill.ca
Clin Endocrinol (Oxf). 2001 Apr;54(4):447-53.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
Lipoprotein 
 
 
 
Related 
52 PCOS 
women with PCOS have increased HL activity ,dense low lipoprotein relative to BMI-matched controls 

 

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