LIF

Gene Information
 
Gene Symbol
LIF
 
Aliases
CDF, DIA, HILDA, MLPLI
 
Entrez Gene ID
 
Gene Name
Leukemia inhibitory factor
 
Chromosomal Location
22q12.2
 
HGNC ID
 
Summary
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. (provided by RefSeq, Oct 2008)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007275 Biological process Multicellular organismal development TAS 3143918
GO:0008284 Biological process Positive regulation of cell proliferation IDA 7957045
GO:0033138 Biological process Positive regulation of peptidyl-serine phosphorylation IDA 7508917
GO:0042517 Biological process Positive regulation of tyrosine phosphorylation of Stat3 protein IDA 12643274
GO:0043410 Biological process Positive regulation of MAPK cascade IDA 7508917
Protein Information
 
Protein Name
Leukemia inhibitory factor
 
Function
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF01291 LIF_OSM LIF / OSM family
 
KEGG
 
OMIM

Associated Diseases

Diseases References
Abortion 16640878, 11930689
Allergy 9034683
Alzheimers disease 18204920, 20074285
Arthritis 1522240, 8318039, 8432990, 7780032, 9099902, 9182920, 8318039, 10685793, 9182920, 1522240, 17477816, 7805751
Atherosclerosis 8148158
   
References
 
Primary:

Follicular fluid concentration of leukaemia inhibitory factor is decreased among women with polycystic ovarian syndrome during assisted reproduction cycles.

Ledee-Bataille N, Lapree-Delage G, Taupin J L, Dubanchet S, Taieb J, Moreau J F, Chaouat G
Service de Gynecologie-Obstetrique et Medecine de la Reproduction, Hopital Antoine Beclere, 157 Rue de la Porte de Trivaux, 92140 Clamart, France. Ledeenathalie@aol.com
Hum Reprod. 2001 Oct;16(10):2073-8.

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
23900753
Differential expression of inflammation-related genes in the ovarian stroma and granulosa cells of PCOS women. 
In vitro 
21851939
Clomiphene citrate versus letrozole: molecular analysis of the endometrium in women with polycystic ovary syndrome. 
Effect of treatment 
21411543, PMC3100753
Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles. 
In vitro 

 

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