LCN2

Gene Information
 
Gene Symbol
LCN2
 
Aliases
24p3, MSFI, NGAL
 
Entrez Gene ID
 
Gene Name
Lipocalin 2
 
Chromosomal Location
9q34
 
HGNC ID
 
Summary
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0070062 Cellular component Extracellular vesicular exosome IDA 19056867
Protein Information
 
Protein Name
25 kDa alpha-2-microglobulin-related subunit of MMP-9, lipocalin-2, migration-stimulating factor inhibitor, oncogene 24p3, siderocalin LCN2
 
Function
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00061 Lipocalin Lipocalin / cytosolic fatty-acid binding protein family
 
OMIM

Associated Diseases

Diseases References
Insulin resistance 20511727
Polycystic ovary syndrome (PCOS) 20511727
   
References
 
Primary:

Serum lipocalin-2 as an insulin resistance marker in patients with polycystic ovary syndrome.

Cakal E, Ozkaya M, Engin-Ustun Y, Ustun Y
Department of Endocrinology, Yuksek Ihtisas Education and Research Hospital, Ankara, Turkey. ermancakal@hotmail.com
J Endocrinol Invest. 2011 Feb;34(2):97-100. doi: 10.3275/7077. Epub 2010 May 28.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
DHEAS 
Insulin resistance, PCOS 
 
 
Related 
30 PCOS, 30 controls 
Serum lipocalin-2 may prove to be a useful marker for insulin resistance in patients with PCOS. 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25145761
The relationship between subclinical cardiovascular disease and lipocalin-2 levels in women with PCOS. 
Clinical study 
23824412, PMC3763978
Mesenchymal stem/progenitors and other endometrial cell types from women with polycystic ovary syndrome (PCOS) display inflammatory and oncogenic potential. 
In vitro 
23337724
Evidence for masculinization of adipokine gene expression in visceral and subcutaneous adipose tissue of obese women with polycystic ovary syndrome (PCOS). 
Clinical study 
23076844
Study of carbohydrate metabolism indices and adipocytokine profile and their relationship with androgens in polycystic ovary syndrome after menopause. 
Clinical study 
21756081
Weight loss significantly reduces serum lipocalin-2 levels in overweight and obese women with polycystic ovary syndrome. 
Clinical study 

 

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