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Gene Symbol |
KLK3 |
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Aliases |
APS, KLK2A1, PSA, hK3 |
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Entrez Gene ID |
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Gene Name |
Kallikrein-related peptidase 3 |
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Chromosomal Location |
19q13.41 |
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HGNC ID |
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Summary |
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)
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UniGene |
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RefSeq mRNA |
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e!Ensembl
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| Protein Information |
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Protein Name |
Prostate-specific antigen |
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Function |
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Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum |
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UniProt |
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PDB |
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InterPro |
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Pfam |
| Pfam Accession |
Pfam ID |
| PF00089 |
Trypsin |
Trypsin |
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KEGG |
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OMIM |
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| Associated Diseases
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References |
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Primary:
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| UKINC Kubilay, Ersoz Halil Onder, Erem Cihangir, Hacihasanoglu Arif Bayram |
| Department of Endocrinology and Metabolism, Karadeniz Technical University, Trabzon, TURKEY. kukinc@comu.edu.tr |
| Endocrine. 2009 Feb;35(1):123-9. doi: 10.1007/s12020-008-9130-6. Epub 2008 Nov |
Abstract
Diagnosis of polycystic ovary syndrome (PCOS) is very difficult in women with ovulatory cycles. We assessed the diagnostic value of prostate-specific antigen (PSA) and free prostate-specific antigen (fPSA) in women with ovulatory or anovulatory PCOS. Study group consisted of 62 women with PCOS and 35 healthy female controls. PCOS group was divided into two subgroups as anovulatory (n = 42; 68%, Group A) and ovulatory group (n = 20; 32%, Group B). A cut-off level of PSA and fPSA was established for the sensitivity, specificity, positive likelihood ratio, area under curve, diagnostic accuracy, and positive and negative predictive values of diagnosis of PCOS. In group A, a PSA level of greater than 10 pg/ml yielded a sensitivity of 73.2%, a specificity of 80%, and a diagnostic accuracy of 73%, with a positive predictive value of 88.2% and a negative predictive value of 59.3%. An fPSA level of greater than 2.1 pg/ml yielded a sensitivity of 71.2%, a specificity of 80.4%, and a diagnostic accuracy of 87%, with a positive predictive value of 87.2% and a negative predictive value of 58.4%. In group B, a PSA level of greater than 10 pg/ml yielded a sensitivity of 65%, a specificity of 80%, and a diagnostic accuracy of 73%, with a positive predictive value of 76.5% and a negative predictive value of 69.6%. An fPSA level of greater than 2.1 pg/ml yielded a sensitivity of 65.4%, a specificity of 80.4%, and a diagnostic accuracy of 87%, with a positive predictive value of 75.5% and a negative predictive value of 68.4%. Circulating androgens and hirsutism are independently associated with the degrees of PSA and fPSA in PCOS women. Increased plasma levels of PSA (>10 pg/ml) and fPSA (>2.1 pg/ml) could be helpful as a diagnostic tool for women with ovulatory or anovulatory PCOS. |
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Supporting Literature:
| PubMed ID |
Associated gene/s |
Associated condition |
Genetic Mutation |
Diagnostic Criteria |
Association with PCOS |
Ethnicity |
Conclusion |
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Free prostate-specific antigen (fPSA) |
Hirsutism |
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Related
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Increased plasma levels of PSA (>10 pg/ml) and fPSA (>2.1 pg/ml) could be helpful as a diagnostic tool for women with ovulatory or anovulatory PCOS |
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DHEAS,SHBG |
Prostatic adenocarcinoma,hyperandrogenism |
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Related
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PSA appears to be a promising marker of endogenous androgen excess in females suffering from PCOS |
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Hyperandrogenism,hirsutism |
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Related
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Serum prostate specific antigen level is higher in patients with PCOS |
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Hyperandrogenism |
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NIH criteria |
Related
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The results of this study indicate that urinary PSA, and possibly urinary hK2, are promising markers of hyperandrogenism in females suffering from PCOS. |
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