KLK3

Gene Information
 
Gene Symbol
KLK3
 
Aliases
APS, KLK2A1, PSA, hK3
 
Entrez Gene ID
354
 
Gene Name
Kallikrein-related peptidase 3
 
Chromosomal Location
19q13.41
 
HGNC ID
 
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0016525 Biological process Negative regulation of angiogenesis NAS 10675891
GO:0005515 Molecular function Protein binding IPI 1725227
GO:0008236 Molecular function Serine-type peptidase activity TAS 2470553
Protein Information
 
Protein Name
Prostate-specific antigen
 
Function
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00089 Trypsin Trypsin
 
KEGG
 
OMIM

Associated Diseases

Diseases References
Hirsutism 19009369, 15233555
Hyperandrogenism 17441890, 15233555, 11297583
Prostatic adenocarcinoma 17441890
   
References
 
Primary:

Diagnostic value of prostate-specific antigen (PSA) and free prostate specific antigen (fPSA) in women with ovulatory and anovulatory polycystic ovary syndrome.

UKINC Kubilay, Ersoz Halil Onder, Erem Cihangir, Hacihasanoglu Arif Bayram
Department of Endocrinology and Metabolism, Karadeniz Technical University, Trabzon, TURKEY. kukinc@comu.edu.tr
Endocrine. 2009 Feb;35(1):123-9. doi: 10.1007/s12020-008-9130-6. Epub 2008 Nov
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
Free prostate-specific antigen (fPSA) 
Hirsutism 
 
 
Related 
 
 Increased plasma levels of PSA (>10 pg/ml) and fPSA (>2.1 pg/ml) could be helpful as a diagnostic tool for women with ovulatory or anovulatory PCOS 
DHEAS,SHBG 
Prostatic adenocarcinoma,hyperandrogenism 
 
 
Related 
 
PSA appears to be a promising marker of endogenous androgen excess in females suffering from PCOS 
 
Hyperandrogenism,hirsutism 
 
 
Related 
 
Serum prostate specific antigen level is higher in patients with PCOS 
 
Hyperandrogenism 
 
NIH criteria 
Related 
 
The results of this study indicate that urinary PSA, and possibly urinary hK2, are promising markers of hyperandrogenism in females suffering from PCOS. 

 

| © 2015, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412