KISS1

Gene Information
 
Gene Symbol
KISS1
 
Aliases
HH13, KiSS-1
 
Entrez Gene ID
 
Gene Name
KiSS-1 metastasis-suppressor
 
Chromosomal Location
1q32
 
HGNC ID
 
Summary
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may function to inhibit chemotaxis and invasion, attenuating metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007010 Biological process Cytoskeleton organization TAS 9192814
GO:0005515 Molecular function Protein binding IPI 11387329
Protein Information
 
Protein Name
Kisspeptin-10
 
Function
Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. Kp-10 is a decapeptide derived from the primary translation product, isolated in conditioned medium of first trimester trophoblast. Kp-10, but not other kisspeptins, increased intracellular Ca(2+) levels in isolated first trimester trophoblasts. Kp-10 is a paracrine/endocrine regulator in fine-tuning trophoblast invasion generated by the trophoblast itself. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood
 
Refseq Proteins
 
UniProt
 
InterPro
Accessions
IPR020207
 
Pfam
Pfam Accession Pfam ID
PF15152 Kisspeptin Kisspeptin
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000356162 Q15726

Associated Diseases

Diseases References
Cancer (carcinoma) 17331419, 19645016, 17659469
Hypertrophy 17488799, 19094085, 18614256
Polycystic ovary syndrome (PCOS) 16650418
Preeclampsia 16202310, 17083831, 15949403
   
References
 
Primary:

Increased plasma metastin levels in adolescent women with polycystic ovary syndrome.

Chen Xiaoli, Mo Yaqin, Li Lin, Chen Yaxiao, Li Yu, Yang Dongzi
Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, No. 107, Yanjiang Road, Guangzhou 510120, Guangdong, China.
Eur J Obstet Gynecol Reprod Biol. 2010 Mar;149(1):72-6.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
LH, FSH, PRL, SHBG, insulin 
 
 
NIH-NICHHD criteria and Rotterdam criteria 
Related 
82 (28 obese PCOS, 28 normal weight PCOS, 13 obese controls, 13 normal weight controls) 
The results of this study indicate that metastin is negatively associated with free androgen levels. The PCOS-associated insulin resistance and consequent hyperinsulinemia probably contribute to this effect by stimulating androgen synthesis by the polycystic ovary (PCO) and suppressing SHBG production in the liver 

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25036703, PMC4109534
A kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF." 
Clinical study 
24829217
Prenatal androgen excess enhances stimulation of the GNRH pulse in pubertal female rats. 
Animal study 
24084835, PMC3901078
Developmental androgen excess disrupts reproduction and energy homeostasis in adult male mice. 
Animal study 
23515450
Treatment and outcomes of precocious puberty: an update. 
Effect of treatment 
22668987
Hypothalamic kiss1 mRNA and kisspeptin immunoreactivity are reduced in a rat model of polycystic ovary syndrome (PCOS). 
Animal study 

 

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