ITLN1

Gene Information
 
Gene Symbol
ITLN1
 
Aliases
HL-1, HL1, INTL, ITLN, LFR, hIntL, omentin
 
Entrez Gene ID
 
Gene Name
Intelectin 1 (galactofuranose binding)
 
Chromosomal Location
1q21.3
 
HGNC ID
 
Summary
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0001934 Biological process Positive regulation of protein phosphorylation IDA 16531507
GO:0046326 Biological process Positive regulation of glucose import IDA 16531507
Protein Information
 
Protein Name
Intelectin-1
 
Function
Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism
 
Refseq Proteins
 
UniProt
 
InterPro
Accessions
IPR002181, IPR014716
 
OMIM
 
Interactions
STRING MINT I2D
ENSP00000323587 Q8WWA0

Associated Diseases

Diseases References
Cardiovascular diseases 17970534
Polycystic ovary syndrome (PCOS) 24524360, 24392647, 18174521
   
References
 
Primary:

Plasma omentin-1 levels are reduced in non-obese women with normal glucose tolerance and polycystic ovary syndrome.

Choi Ji-Hun, Rhee Eun-Jung, Kim Kye-Hyun, Woo Hee-Yeon, Lee Won-Young, Sung Ki-Chul
Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110-746, Korea.
Eur J Endocrinol. 2011 Nov;165(5):789-96. Epub 2011 Aug 24.
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
 
 
 
Related 
81 lean and obese women with PCOS, 61 lean and obese controls  
In conclusion, fat mass seems to be the main determinant factor of increased chemerin and decreased omentin in women with PCOS 
 
 
 
 
Direct 
87 PCOS (obese), 72 non-PCOS women (41 obese) 
Omentin-1 level was significantly lower in the PCOS compared with the non-PCOS group, and not related to body mass 
 
 
 
 
Related 
 
Decreased plasma omentin-1 levels was observed in women with PCOS, compared with control subjects, there was significantly lower levels of omentin-1 mRNA and protein in omental adipose tissue of women with PCOS 

Unreviewed Literature:

Show/Hide all(5)
PubMed / PMC ID
Title Type of study
24943040
Expression and regulation of INTELECTIN1 in human granulosa-lutein cells: role in IGF-1-induced steroidogenesis through NAMPT. 
In vitro 
23337724
Evidence for masculinization of adipokine gene expression in visceral and subcutaneous adipose tissue of obese women with polycystic ovary syndrome (PCOS). 
Clinical study 
22309615
Relationship among plasma adipokines, insulin and androgens level as well as biochemical glycemic and lipidemic markers with incidence of PCOS in women with normal BMI. 
Clinical study 
21865408
Plasma omentin-1 levels are reduced in non-obese women with normal glucose tolerance and polycystic ovary syndrome. 
Clinical study 
20852028, PMC2992762
Metformin treatment may increase omentin-1 levels in women with polycystic ovary syndrome. 
Effect of treatment 

 

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