ITGAM

Gene Information
 
Gene Symbol
ITGAM
 
Aliases
CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6
 
Entrez Gene ID
 
Gene Name
Integrin, alpha M (complement component 3 receptor 3 subunit)
 
Chromosomal Location
16p11.2
 
HGNC ID
 
Summary
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Mar 2009)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007155 Biological process Cell adhesion TAS 2563162
GO:0001948 Molecular function Glycoprotein binding IPI 15004192
GO:0005515 Molecular function Protein binding IPI 15194813
Protein Information
 
Protein Name
SLEB6 , leukocyte adhesion receptor MO1 , Leukocyte adhesion receptor MO1 , neutrophil adherence receptor alpha-M subunit , integrin, alpha M (complement component receptor 3, alpha; also known as CD11b (p170), macrophage antigen alpha polypeptide) , macrophage antigen alpha polypeptide , CD11B , cell surface glycoprotein MAC-1 subunit alpha , CD11 antigen-like family member B , CD11b antigen , MAC1A , Cell surface glycoprotein MAC-1 subunit alpha , integrin, alpha M (complement component 3 receptor 3 subunit) , MAC-1 , CR-3 alpha chain , CR3A , integrin alpha-M , antigen CD11b (p170) , Neutrophil adherence receptor , MO1A
 
Function
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
 
UniProt
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF01839 FG-GAP
PF00357 Integrin_alpha
PF08441 Integrin_alpha2
PF00092 VWA
 
KEGG
 
OMIM
 
Phenotype MIM ID

Associated Diseases

Diseases References
Polycystic ovary syndrome (PCOS) 22945299
   
References
 
Primary:

Expression of the CD11c gene in subcutaneous adipose tissue is associated with cytokine level and insulin resistance in women with polycystic ovary syndrome.

Tao Tao, Li Shengxian, Zhao Aimin, Zhang Yanyun, Liu Wei
Division of Endocrinology and Metabolism, Department of Internal Medicine, Shanghai Jiaotong University School of Medicine, Renji Hospital, Pudong, People's Republic of China.
Eur J Endocrinol. 2012 Nov;167(5):705-13. doi: 10.1530/EJE-12-0340. Epub 2012 Sep
 
Supporting Literature:
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
 
 
 
Direct 
16 PCOS women, 18 normal control women 
The high expression level of CD11c mRNA in SAT was proved to be an important feature in PCOS women 

 

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