INSL3

Gene Information
 
Gene Symbol
INSL3
 
Aliases
RLF, RLNL, ley-I-L
 
Entrez Gene ID
 
Gene Name
Insulin-like 3 (Leydig cell)
 
Chromosomal Location
19p13.2-p12
 
HGNC ID
 
Summary
The protein encoded by this gene is an insulin like hormone produced mainly in gonadal tissues in males and females. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. It may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. The mutations in this gene may lead to, but not a frequent cause of, cryptorchidism. (provided by RefSeq)
 
GeneCards ID
 
UniGene
 
RefSeq DNA
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0007165 Biological process Signal transduction TAS 8020942
GO:0007267 Biological process Cell-cell signaling TAS 8253799
GO:0007283 Biological process Spermatogenesis TAS 8253799
GO:0004871 Molecular function Signal transducer activity TAS 8020942
GO:0005102 Molecular function Receptor binding TAS 8020942
Protein Information
 
Protein Name
Insulin-like 3 A chain
 
Function
Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
Accessions
IPR016179, IPR022353
 
Pfam
Pfam Accession Pfam ID
PF00049 Insulin Insulin/IGF/Relaxin family
 
OMIM
 
Phenotype MIM ID
 
Interactions
STRING MINT I2D
ENSP00000321724 P51460

Associated Diseases

Diseases References
Cancer (carcinoma) 12684664, 16010410
Cryptorchidism 11992081, 15533513, 11383919, 11380919
Hyperandrogenism 16926256, 17356050
Infertility 16687567, 15956751, 15579743
Obesity 19226271, 17014531
   
References
 
Primary:

Basal insulin-like factor 3 levels predict functional ovarian hyperandrogenism in the polycystic ovary syndrome.

Gambineri A, Patton L, Prontera O, Fanelli F, Ciampaglia W, Cognigni G E, Pagotto U, Pasquali R
Department of Internal Medicine, S. Orsola-Malpighi Hospital, Bologna, Italy.
J Endocrinol Invest. 2011 Oct;34(9):685-91. Epub 2011 May 17.

Unreviewed Literature:

PubMed / PMC ID
Title Type of study
25887459, PMC4414284
Polycystic ovarian syndrome is accompanied by repression of gene signatures associated with biosynthesis and metabolism of steroids, cholesterol and lipids. 
Animal study 
24014601
Circulating insulin-like factor 3 (INSL3) in healthy and infertile women. 
Clinical study 
23115068
Insulin-like factor 3 -- a new hormone related to polycystic ovary syndrome? 
Clinical study 
21586896
Basal insulin-like factor 3 levels predict functional ovarian hyperandrogenism in the polycystic ovary syndrome. 
Clinical study 

 

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