IL6ST

Gene Information
 
Gene Symbol
IL6ST
 
Aliases
CD130, CDW130, GP130, IL-6RB
 
Entrez Gene ID
 
Gene Name
Interleukin 6 signal transducer
 
Chromosomal Location
5q11.2
 
HGNC ID
 
Summary
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. (provided by RefSeq, Jul 2010)
 
GeneCards ID
 
UniGene
 
RefSeq mRNA
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Definition Evidence Reference
GO:0002675 Biological process Positive regulation of acute inflammatory response IC 8999038
GO:0002821 Biological process Positive regulation of adaptive immune response IC 14764690
GO:0008284 Biological process Positive regulation of cell proliferation IGI 8999038
GO:0010575 Biological process Positive regulation vascular endothelial growth factor production TAS 10744750
GO:0010613 Biological process Positive regulation of cardiac muscle hypertrophy TAS 10744750
Protein Information
 
Protein Name
Interleukin-6 receptor subunit beta
 
Function
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events
 
Refseq Proteins
 
UniProt
 
PDB
 
InterPro
 
Pfam
Pfam Accession Pfam ID
PF00041 fn3 Fibronectin type III domain
PF06328 Lep_receptor_Ig Ig-like C2-type domain
PF09240 IL6Ra-bind Interleukin-6 receptor alpha chain, binding
 
KEGG
 
OMIM

Associated Diseases

Diseases References
Polycystic ovary syndrome (PCOS) 20103703
   
References
 
Primary:

Serum soluble glycoprotein 130 concentration is inversely related to insulin sensitivity in women with polycystic ovary syndrome.

Nikolajuk Agnieszka, Kowalska Irina, Karczewska-Kupczewska Monika, Adamska Agnieszka, Otziomek Elzbieta, Wolczynski Slawomir, Kinalska Ida, Gorska Maria, Straczkowski Marek
Department of Endocrinology, Diabetology, and Internal Medicine, Medical University of Bialystok, Bialystok, Poland.
Diabetes. 2010 Apr;59(4):1026-9. doi: 10.2337/db09-1316. Epub 2010 Jan 26.

 

| © 2015, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
Tel: 91-22-24192104, Fax No: 91-22-24139412